Detection of cell death markers as a tool for bacterial antimicrobial susceptibility testing

1. Choi M-J, Ko KS. Mutant prevention concentrations of colistin for Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae clinical isolates. J Antimicrob Chemother, 2014;69(1):275–277.

2. Canton R, Akova M, Carmeli Y, et al. Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe. Clin Microbiol Infect, 2012;18(5):413–431.

3. Cornaglia G, Akova M, Amicosante G, et al. Metallo-beta-lactamases as emerging resistance determinants in Gram-negative pathogens: open issues. Int J Antimicrob Agents, 2007;29(4):380–388.

4. Bou G, Martinez-Beltran J. Cloning, nucleotide sequencing, and analysis of the gene encoding an AmpC beta-lactamase in Acinetobacter baumannii. Antimicrob Agents Chemother, 2000;44(2):428–432.

5. Endimiani A, Luzzaro F, Migliavacca R, et al. Spread in an Italian hospital of a clonal Acinetobacter baumannii strain producing the TEM-92 extended-spectrum beta-lactamase. Antimicrob Agents Chemother, 2007;51(6):2211–2214.

6. Muller C, Plesiat P, Jeannot K. A two-component regulatory system interconnects resistance to polymyxins, aminoglycosides, fluoroquinolones, and beta-lactams in Pseudomonas aeruginosa. Antimicrob Agents Chemother, 2011;55(3):1211–1221.

7. Wang M, Borris L, Aarestrup FM, et al. Identification of a Pseudomonas aeruginosa co-producing NDM-1, VIM-5 and VIM-6 metallo-beta-lactamases in Denmark using whole-genome sequencing. Int J Antimicrob Agents, 2015;45(3):324–325.

8. Cernohorska L, Slavikova P. Antibiotic resistance and biofilm formation in Pseudomonas aeruginosa strains isolated from patients with urinary tract infections. Epidemiol Mikrobiol Imunol, 2009;58(4):154–157.

9. Moker N, Dean CR, Tao J. Pseudomonas aeruginosa increases formation of multidrug-tolerant persister cells in response to quorum-sensing signaling molecules. J Bacteriol, 2010;192(7):1946–1955.

10. Overhage J, Bains M, Brazas MD, et al. Swarming of Pseudomonas aeruginosa is a complex adaptation leading to increased production of virulence factors and antibiotic resistance. J Bacteriol, 2008;190(8):2671–2679.

11. Khakimova M, Ahlgren HG, Harrison JJ, et al. The stringent response controls catalases in Pseudomonas aeruginosa and is required for hydrogen peroxide and antibiotic tolerance. J Bacteriol, 2013;195(9):2011–2020.

12. Hrabak J, Walkova R, Studentova V, et al. Carbapenemase activity detection by matrix-assisted laser desorption ionization-time of flight mass spectrometry. J Clin Microbiol, 2011; 49(9):3222–3227.

13. Mlynarcik P, Kolar M, Roderova M. New technologies for antibiotic susceptibility testing of bacteria. Klin Mikrobiol Infekc Lek, 2014;20(3):72–78.

14. Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer, 1972;26(4):239–257.

15. Dwyer DJ, Camacho DM, Kohanski MA, et al. Antibiotic-induced bacterial cell death exhibits physiological and biochemical hallmarks of apoptosis. Mol Cell, 2012;46(5):561–572.

16. Drlica K, Malik M, Kerns RJ, et al. Quinolone-mediated bacterial death. Antimicrob Agents Chemother, 2008;52(2):385–392.

17. Floss HG, Yu T-W. Rifamycin-mode of action, resistance, and biosynthesis. Chem Rev, 2005;105(2):621–632.

18. Tomasz A. The mechanism of the irreversible antimicrobial effects of penicillins: how the beta-lactam antibiotics kill and lyse bacteria. Annu Rev Microbiol, 1979;33:113–137.

19. Vakulenko SB, Mobashery S. Versatility of aminoglycosides and prospects for their future. Clin Microbiol Rev, 2003;16(3):430–450.

20. Dwyer DJ, Kohanski MA, Collins JJ. Role of reactive oxygen species in antibiotic action and resistance. Curr Opin Microbiol, 2009;12(5):482–489.

21. Kohanski MA, Dwyer DJ, Hayete B, et al. A common mechanism of cellular death induced by bactericidal antibiotics. Cell, 2007;130(5):797–810.

22. Dixon SJ, Stockwell BR. The role of iron and reactive oxygen spe­cies in cell death. Nat Chem Biol, 2014;10(1):9–17.

23. Kohanski MA, Dwyer DJ, Wierzbowski J, et al. Mistranslation of membrane proteins and two-component system activation trigger antibiotic-mediated cell death. Cell, 2008;135(4):679–690.

24. Keren I, Wu Y, Inocencio J, et al. Killing by bactericidal antibiotics does not depend on reactive oxygen species. Science, 2013;339(6124):1213–1216.

25. Allison KR, Brynildsen MP, Collins JJ. Metabolite-enabled eradication of bacterial persisters by aminoglycosides. Nature, 2011;473(7346):216–220.

26. Dwyer DJ, Belenky PA, Yang JH, et al. Antibiotics induce redox-related physiological alterations as part of their lethality. Proc Natl Acad Sci USA, 2014;111(20):E2100–E2109.

27. Breidenstein EB, Khaira BK, Wiegand I, et al. Complex ciprofloxacin resistome revealed by screening a Pseudomonas aeruginosa mutant library for altered susceptibility. Antimicrob Agents Chemother, 2008;52(12):4486–4491.

28. Nguyen D, Joshi-Datar A, Lepine F, et al. Active starvation responses mediate antibiotic tolerance in biofilms and nutrient-limited bacteria. Science, 2011;334(6058):982–986.

29. Butala M, Zgur-Bertok D, Busby SJW. The bacterial LexA transcriptional repressor. Cell Mol Life Sci, 2009;66(1):82–93.

30. Erental A, Sharon I, Engelberg-Kulka H. Two programmed cell death systems in Escherichia coli: an apoptotic-like death is inhibited by the mazEF-mediated death pathway. PLoS Biol, 2012;10(3):e1001281.

31. Kolodkin-Gal I, Engelberg-Kulka H. Induction of Escherichia coli chromosomal mazEF by stressful conditions causes an irreversible loss of viability. J Bacteriol, 2006;188(9):3420–3423.

32. Belitsky M, Avshalom H, Erental A, et al. The Escherichia coli extracellular death factor EDF induces the endoribonucleolytic activities of the toxins MazF and ChpBK. Mol Cell, 2011;41(6):625–635.

33. Pandey DP, Gerdes K. Toxin-antitoxin loci are highly abundant in free-living but lost from host-associated prokaryotes. Nucleic Acids Res, 2005;33(3):966–976.

34. Yeom J, Imlay JA, Park W. Iron homeostasis affects antibiotic-mediated cell death in Pseudomonas species. J Biol Chem, 2010;285(29):22689–22695.

35. Aizenman E, Engelberg-Kulka H, Glaser G. An Escherichia coli chromosomal "addiction module" regulated by guanosine [corrected] 3',5'-bispyrophosphate: a model for programmed bacterial cell death. Proc Natl Acad Sci USA, 1996;93(12):6059–6063.

36. Pepper ED, Farrell MJ, Nord G, et al. Antiglycation effects of carnosine and other compounds on the long-term survival of Escherichia coli. Appl Environ Microbiol, 2010; 76(24):7925–7930.

37. Goltermann L, Good L, Bentin T. Chaperonins fight aminoglycoside-induced protein misfolding and promote short-term tolerance in Escherichia coli. J Biol Chem, 2013;288(15): 10483–10489.

38. Carmona-Gutierrez D, Kroemer G, Madeo F. When death was young: an ancestral apoptotic network in bacteria. Mol Cell, 2012;46(5):552–554.

39. Martin-Pena R, Dominguez-Herrera J, Pachon J, et al. Rapid detection of antibiotic resistance in Acinetobacter baumannii using quantitative real-time PCR. J Antimicrob Chemother, 2013;68(7):1572–1575.

40. van Belkum A, Dunne WM, Jr. Next-generation antimicrobial susceptibility testing. J Clin Microbiol, 2013;51(7):2018–2024.

41. Hood MI, Becker KW, Roux CM, et al. genetic determinants of intrinsic colistin tolerance in Acinetobacter baumannii. Infect Immun, 2013;81(2):542–551.

42. Henry R, Vithanage N, Harrison P, et al. Colistin-resistant, lipopolysaccharide-deficient Acinetobacter baumannii responds to lipopolysaccharide loss through increased expression of genes involved in the synthesis and transport of lipoproteins, phospholipids, and poly-beta-1,6-N-acetylglucosamine. Antimicrob Agents Chemother, 2012;56(1):59–69.