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Subependymálny obrovskobunkový astrocytóm s atypickými klinickými a patologickými črtami: diagnostická pasca


Authors: Marián Švajdler jr. 1;  Ladislav Deák 2;  Boris Rychlý 3;  Peter Talarčík 3;  Lucia Fröhlichová 1
Authors‘ workplace: Department of pathology, L. Pasteur’s University Hospital, Košice, Slovakia 1;  Department of pediatric oncology and haematology, Children’s University Hospital, Košice, Slovakia 2;  Cytopathos s. r. o., Bratislava, Slovakia 3
Published in: Čes.-slov. Patol., 49, 2013, No. 2, p. 76-79
Category: Original Article

Overview

Subependymálny obrovskobunkový astrocytóm (SEGA) je benígny pomaly rastúci tumor asociovaný so syndrómom tuberóznej sklerózy. Vyskytuje sa takmer výlučne v oblasti foramen Monro. Šírene do parenchýmu hemisféry a znepokojujúce histologické črty ako sú nekrózy, mitózy, mikrovaskulárna proliferácia a pleomorfia sú nezvyčajné, ale vzácne môžu byť prítomné. Prezentujeme prípad SEGA u pacienta, u ktrorého zatiaľ nie sú prítomné ďalšie známky syndrómu tuberóznej sklerózy, s atypickým radiologickým nálezom a mikroskopicky prítomnými nekrózami. Tieto znepokojujúce črty iniciálne viedli k nesprávnej diagnóze glioblastómu. Je diskutovaná diferenciálna diagnóza SEGA.

Kľúčové slová:
subependymálny obrovskobunkový astrocytóm – atypický – nekróza


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