Difuzní idiopatická hyperplázie neuroendokrinních buněk: popis případu a přehled literatury
:
Jana Dvořáčková 1,2; Jirka Mačák 1; Petr Buzrla 1
:
Department of Pathology, Faculty of Medicine, University of Ostrava and University Hospital Ostrava, Czech Republic
1; CGB laboratory Inc., Ostrava, Czech Republic
2
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Čes.-slov. Patol., 49, 2013, No. 2, p. 99-102
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Original Article
Difuzní idiopatická plicní hyperplázie neuroendokrinních buněk je vzácné onemocnění, které postihuje většinou ženy v 5. a 6. dekádě života. Prezentujeme náhodný nález tohoto onemocnění u 56-leté ženy, nekuřačky. Na periferii středního laloku pravé plíce byla zjištěna lineární a nodulární proliferace neuroendokrinních buněk ve stěně malých bronchů a v terminálních a respiračních bronchiolech. Pod pleurou bylo zjištěno několik tumorletů. Imunohistologicky neuroendokrinní buňky reagovaly pozitivně s protilátkami proti chromograninu, synaptofysinu, CD56, serotoninu (slabá pozitivita jen některých buněk), kalcitoninu, GRP/bombesinu, CK7 a TTF-1.
Klíčová slova:
difuzní idiopatická hyperplázie neuroendokrinních buněk – tumorlety – neuroendokrinní tumory – imunohistochemie
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