Perineurióm podobný angiofibrómu. Kazuistika
Authors:
Michal Zámečník 1; Petr Mukenšnabl 2; Alena Chlumská 2,3
Authors‘ workplace:
Medicyt s. r. o., Laboratory of Surgical Pathology, Trenčín, Slovak Republic
1; Šikl`s Department of Pathology, Medical Faculty Hospital, Charles University, Pilsen, Czech Republic
2; Laboratory of Surgical Pathology, Pilsen, Czech Republic
3
Published in:
Čes.-slov. Patol., 49, 2013, No. 2, p. 86-88
Category:
Original Article
Overview
Prezentujeme prípad perineuriómu s neobvykle bohatou vaskularizáciou, ktorá spôsobila podobnosť s angiofibrómom. Šlo o dermálny/subkutánny tumor ľavého ramena u 58-ročného muža. Tumor mal rozmery 2,5 x 2 x 2 cm. Histologicky bol tvorený blandnými fibroblastoidnými bunkami usporiadanými zväčša nepravidelne, len s ojedinelým špirálovitým radením okolo ciev. Malé množstvo buniek malo bipolárne tenké výbežky. Cievy predstavovali druhú prominentnú zložku lézie. Imunohistochemicky bola zistená expresia perineurálnych markerov (EMA, klaudín-1 a CD34) v perivaskulárnych bunkách a v malej časti buniek vzdialených od ciev. Tumor bol ďalej difúzne pozitívny na CD10. Náš nález ukazuje, že diagnózu perineuriómu je potrebné zvažovať aj pri bohato vaskularizovaných léziach s „angiofibroma-like“ morfológiou. Demonštrovaný prípad perineuriómu sa veľmi podobal na recentne popísaný angiofibróm mäkkých tkanív (u ktorého bola často pozorovaná aj expresia EMA).
Kľúčové slová:
perineurióm – angiofibróm – mäkké tkanivá – EMA – klaudín-1
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Anatomical pathology Forensic medical examiner ToxicologyArticle was published in
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