Current view on the diagnostics of growth hormone deficiency in childhood and adolescence
Authors:
Plachý Lukáš; Maratová Klára; Veselá Karolína; Lebl Jan; Průhová Štěpánka
Authors‘ workplace:
Pediatrická klinika, 2. lékařská fakulta, Univerzita Karlova a FN Motol, Praha
Published in:
Čes-slov Pediat 2023; 78 (S3): 5-10.
Category:
Comprehensive Report
doi:
https://doi.org/10.55095/CSPediatrie2023/056
Overview
Optimal growth hormone (GH) production, secretion and function are essential for physiological human growth. Relevant assessment of growth hormone deficiency (GHD) is crucial for an early initiation of GH substitution aiming to improve body height and to prevent hypoglycemia and other consequences of GHD. However, even 60 years after the launch of first GH laboratory assay, diagnosis of GHD still faces technical and interpretational problems. GH stimulation tests are considered the golden standard to diagnose GHD, however their specificity is low, and therefore frequently generating false pathologic results. Therefore, diagnosis of GHD requires a complex evaluation of the patient history and auxological data on the background of stimulation testes, IGF-1 level, and of imaging methods and genetic testing in selected cases.
Keywords:
short stature, growth hormone, growth hormone deficiency
Sources
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Labels
Neonatology Paediatrics General practitioner for children and adolescentsArticle was published in
Czech-Slovak Pediatrics
2023 Issue S3
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