Failure of Vaccination against Haemophilus Influenzae Type b

Czech version

Authors: J. Táborská ¹; V. Gutová ²; A. Koubová ¹; P. Pazdiora ³; V. Lebedová ⁴
Authors‘ workplace: Infekční klinika Fakultní nemocnice, Plzeň přednostka MUDr. J. Táborská, PhD. ¹; Ústav imunologie a alergologie LF UK, Plzeň přednosta doc. MUDr. P. Panzner, CSc. ²; Ústav epidemiologie LF UK, Plzeň vedoucí doc. MUDr. P. Pazdiora, CSc. ³; Národní referenční laboratoř pro hemofilové nákazy, Centrum epidemiologie a mikrobiologie, SZÚ, Praha vedoucí MUDr. V. Lebedová ⁴
Published in: Čes-slov Pediat 2005; 60 (5): 288-292.
Category: Case Report

Overview

The authors present a case report of a 19-month child regularly vaccinated with three doses of the vaccine against invasive infections caused by Haemophilus influenzae type b (Hib). In spite of that the patient suffered from bacterial meningitis caused exactly by this microbial strain. The immunological examination demonstrated a deficiency of serum immunoglobulins IgA and IgG, which was probably the cause of insufficient production of antibodies against polyribosil-ribitolphosphate (PRP) antigen Hib after the vaccination and, also, the cause of the disease development. The problems in failure of vaccination against Hib are discussed.

Key words:
Haemophilus influenzae type b, vaccination, meningitis

Labels

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Article was published in

Czech-Slovak Pediatrics

2005 Issue 5