#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#
proLékaře.cz / Journals / Czech-Slovak Dermatology / 2024 - 2

Calcification and Ossification in Dermatology and Dermatopathology

Czech version

Authors: M. Důra;  J. Štork
Authors‘ workplace: Dermatovenerologická klinika 1. LF UK a VFN, přednosta prof. MUDr. Jiří Štork, CSc.
Published in: Čes-slov Derm, 99, 2024, No. 2, p. 48-60
Category: Reviews (Continuing Medical Education)

Overview

Pathological calcification in the skin and subcutaneous tissue is relatively heterogenous issue. From the etiopathogenetic point of view, the pathological calcifications are divided into dystrophic, metastatic, idiopathic, and iatrogenic type. Calciphylaxis is distinguished as a distinctive type.

Ectopic ossification in dermatology is a rare phenomenon, which arises as an isolated finding or as a part of the range of tumours, in which the ossification is a typical feature.

The article summarizes the topic of the pathological calcification and the ectopic ossification in dermatology and dermatopathology. The paper presents the definition, the brief description of the etiopathogenesis and the list of the most common diseases connected to the particular types of the pathological calcium deposition in the skin, the subcutaneous tissue and the soft tissue. The review also summarizes the problematics of the osteoma cutis from the view of the clinical picture and the histopathology. Finally, the short summary of the diagnostic and therapeutic alternatives is discussed.

Keywords:

dystrophic calcification – metastatic calcification – idiopathic calcification – calciphylaxis – ossification – osteoma cutis

Sources
  1. ADYA, K. A., INAMADAR, A. C. Clinical, dermoscopic and radiological features of heel stick calcinosis cutis. Dermatol Pract Concept, 2022, 12 (3), p. e2022108.
  2. ARAGHI, F., DADKHAHFAR, S., TABARY, M., RAKHSHAN, A., GHEISARI, M. Progressive primary plate-like osteoma cutis of the scalp. Skin Appendage Disord, 2021, 7 (3), p. 216–219.
  3. BEATTY, P., KILLION, L., POWER, R., ROCHE, M. Dystrophic calcinosis cutis successfully treated with extracorporeal shockwave lithotripsy. Clin Exp Dermatol, 2021, 46 (8), p. 1656–1658.
  4. BENSON, J. C., TREJO-LOPEZ, J. A., NASSIRI, A. M.et al. Phosphaturic mesenchymal tumor. AJNR Am J Neuroradiol, 2022, 43 (6), p. 817–822.
  5. BOLOGNIA, J., JORIZZO, J. L., SCHAFFER, J. V. Dermatology. 3rd Edition. Philadelphia: Elsevier/Saunders, 2012, 2, p. 729–736. ISBN 978-0723435716.
  6. CAGGIATI, A., MOSTI, G. Subcutaneous calcifications in legs with chronic venous diseases. J Vasc Surg Venous Lymphat Disord, 2022, 10 (3), p. 689–696.
  7. CALONJE, E., BRENN, T., LAZAR, A. J. et al. McKee‘s Pathology of the Skin. 5th Edition. Amsterdam: Elsevier/Saunders, 2019, 2 vol., p. 370–371. ISBN978-0-7020-6983-3.
  8. COCKS, M., HELMKE, E., MEYERS, C. A., FAYAD,L., MCCARTHY, E., JAMES, A. W. Bizarre parosteal osteochondromatous proliferation: 16 cases with a focus on histologic variability. J Orthop, 2018, 15 (1), p. 138–142.
  9. DAVULURI, S., DUVVURI, B., LOOD, C., FAGHIHI-KASHANI, S., CHUNG, L. Calcinosis in dermatomyositis: Origins and possible therapeutic avenues. Best Pract Res Clin Rheumatol, 2022, 36 (2), p. 101768.
  10. DEL BARRIO-DÍAZ, P., MOLL-MANZUR, C., ÁLVAREZ-VELIZ, S., VERA-KELLET, C. Topical sodium metabisulfite for the treatment of calcinosis cutis: a promising new therapy. Br J Dermatol, 2016, 175 (3), p. 608–611.
  11. DEZA, G., SÁNCHEZ-SCHMIDT, J. M., PUJOL, R. M. Solitary plaque-type morphea with dystrophic calcinosis cutis. Acta Derm Venereol, 2016, 96 (3), p. 418–419.
  12. DUARTE-SUMMERS, A., BISTLINE, A., PATEL, V. et al. A rare presentation of secondary multiple miliary osteoma cutis. JAAD Case Rep, 2023, 33, p. 84–86.
  13. DŮRA, M., PETRÁČKOVÁ, M., ŠTORK, J. Mnohočetné papuly na tvářích. Stručný přehled. Čes-slov Derm, 2023, 98 (3), p. 160–162.
  14. ELAHMAR, H., FELDMAN, B. M., JOHNSON, S. R. Management of calcinosis cutis in rheumatic diseases. J Rheumatol, 2022, 49 (9), p. 980–989.
  15. FOROUZAN, P., CALAME, A., UEBELHOER, N. S., COHEN, P. R. Basal cell carcinoma with calcification: Case report of calcifying basal cell carcinoma and review of calcinosis cutis associated with basal cell carcinoma. Cureus, 2021, 13 (1), e12721.
  16. GORREPATI, P. L., SMITH, G. P. Treatments for calcinosis cutis in autoimmune connective tissue diseases. J Am Acad Dermatol, 2022, 87 (5), p. 1211–1212.
  17. GRAZZINI, M., BASSI, A., MAZZATENTA, C. Milia-like idiopathic calcinosis cutis: when waiting is the best option. J Pediatr, 2020, 224, p. 173–174.
  18. HAVLÁN, P., CÍSAŘOVÁ, K., ČEPELOVÁ, E. Tvrdé noduly na skrotu. Stručný přehled. Čes-slov Derm, 2021, 96 (5), p. 227–229.
  19. HORGAN, T., MCNAMARA, C., IRELAND, A., SANDY, J., PURYER, J. Calcifying acne: An unusual extraoral radiographic finding. Case Rep Dent, 2017, 2017, p. 3514936.
  20. HOWARD, R. M., SMITH, G. P. Treatment of calcinosis cutis with sodium thiosulfate therapy. J Am Acad Dermatol, 2020, 83 (5), p. 1518–1520.
  21. CHAUDHRY, I. H., KAZAKOV, D. V., MICHAL, M., MENTZEL, T., LUZAR, B., CALONJE, E. Fibro-osseous pseudotumor of the digit: a clinicopathological study of 17 cases. J Cutan Pathol, 2010, 37 (3), p. 323–329.
  22. JEREMIC, I. R., SIMEUNOVIC, B., DOLIJANOVIC, S. P., MANOJLOVIC GACIC, E. Calcinosis cutis in a patient with systemic lupus erythematosus: Casebased review. The Egyptian Rheumatologist, 2023, 45 (4), p. 333–337.
  23. JOSHI, R. Venetian blinds‘ artifact in dermatohistopathology. Indian Dermatol Online J, 2012, 3 (1), p. 59–61.
  24. KALLEN, M. E., MICHAL, M., MEYER, A. et al. Calcified chondroid mesenchymal neoplasm: Exploring the morphologic and clinical features of an emergent entity with a series of 33 cases. Am J Surg Pathol, 2023, 47 (6), p. 725–737.
  25. KOVÁČIKOVÁ CURKOVÁ, A., RASOCHOVÁ, E. Pseudoxanthoma elasticum. Čes-slov Derm, 2010, 85 (4), p. 219–223.
  26. KRISTLOVÁ, H., BOČKOVÁ, J., HORAŽĎOVSKÝ, J. et al. Apremilast v léčbě ulcerací při suspektní non-uremické kalcifylaxi. Popis případu. Čes-slov Derm, 2021, 96, (3), p. 142–148.
  27. LAGUNA, E. V., MARTINEZ, A. A., BURGOS, F. Petrified ear – a case of calcinosis cutis. Acta Derm Venereol, 2009, 89 (5), p. 527–528.
  28. LAI, N. K., MARTINEZ, D. Physiological roles of parathyroid hormone-related protein. Acta Biomed, 2019, 90 (4), p. 510–516.
  29. LAL, N. R., BANDYOPADHYAY, D., VERMA, R., SHUKLA, A. K. Perforating calcific elastosis: Revisiting a rare entity. Indian J Dermatol, 2018, 63 (2), p. 186–188.
  30. LEE, S. S., BAKER, B. L., GAPP, J. D., ROSENBERG, A. E., GOOGE, P. B. Ossifying plexiform tumor. J Cutan Pathol, 2015, 42 (1), p. 61–65.
  31. LIN, S. Y. Biochemical and molecular aspects of spectral diagnosis in calcinosis cutis. Expert Rev Mol Med, 2014, 16, p. e6.
  32. LOPEZ, A. T., GROSSMAN, M. E. Facial calcinosis cutis in a patient with systemic lupus erythematosus: A case report of tissue injury owing to photosensitivity as the cause of dystrophic calcification. JAAD Case Rep, 2017, 3 (5), p. 460–463.
  33. MA, J. E., ERNSTE, F. C., DAVIS, M. D. P., WETTER, D. A. Topical sodium thiosulfate for calcinosis cutis associated with autoimmune connective tissue diseases: the Mayo Clinic experience, 2012–2017. Clin Exp Dermatol, 2019, 44 (5), p. e189–e192.
  34. MEDINA, Y. F., ROLON, M., IGLESIAS, A. Calcifying lupus panniculitis in a patient without manifestations of systemic lupus erythematosus. Revista Colombiana de Reumatologia, 2011, 18 (2), p. 140–145.
  35. MEISSNER, M., KLEEMANN, J., KAUFMANN, R., OCHSENDORF, F. The erbium:YAG laser: a new technique for the treatment of scrotal calcinosis. J Eur Acad Dermatol Venereol, 2017, 31 (4), e207–e209.
  36. MULKAREDDY, V., BHALLA, V., UPADHYE, S., SIDDAM, P. The diagnostic dilemma of sarcoidosis: A case of acute hypercalcemia. Cureus, 2020, 12 (9), p. e10399.
  37. NIEBEL, D., POORTINGA, S., WENZEL, J. Osteomacutis and calcinosis cutis: „similar but different“. J Clin Aesthet Dermatol, 2020, 13 (11), p. 28–31.
  38. PACHECO COMPAÑA, F. J., MIDÓN MÍGUEZ, J., DE TORO SANTOS, F. J. Lesions associated with calcium gluconate extravasation: Presentation of 5 clinical cases and analysis of cases published. Ann Plast Surg, 2017, 79 (5), p. 444–449.
  39. PAGNONI, A., GIROUD, S., KOULOURI, A., HOHL, D., GAIDE, O. White globules in basal cell carcinoma: A dermoscopic sign with preoperative implications. Dermatol Pract Concept, 2020, 11 (1), e2021103.
  40. RICK, J., RRAPI, R., CHAND, S. et al. Calciphylaxis: Treatment and outlook-CME part II. J Am Acad Dermatol, 2022, 86 (5), p. 985–992.
  41. RICK, J., STROWD, L., PASIEKA, H. B. et al. Calciphylaxis: Part I. Diagnosis and pathology. J Am Acad Dermatol, 2022, 86 (5), p. 973–982.
  42. SEGUÍ, M., RODRÍGUEZ-JIMÉNEZ, P., FRAGA, J. et al. Pancreatic panniculitis revisited: A series of 34 patients. J Cutan Pathol, 2023, 50 (11), p. 983–990.
  43. SHAHI, V., WETTER, D. A., HOWE, B. M., RINGLER, M. D., DAVIS, M. D. Plain radiography is effective for the detection of calcinosis cutis occurring in association with autoimmune connective tissue disease. Br J Dermatol, 2014, 170 (5), p. 1073–1079.
  44. SMITH, G. P. Intradermal sodium thiosulfate for exophytic calcinosis cutis of connective tissue disease. J Am Acad Dermatol, 2013, 69 (3), e146–147.
  45. SOLANKI, A., NARANG, S., KATHPALIA, R., GOEL, A. Scrotal calcinosis: pathogenetic link with epidermal cyst. BMJ Case Rep, 2015, 2015, bcr2015211163.
  46. TKACHENKO, E., PIERSON, J. C., VLEUGELS, R. A. Porphyria cutanea tarda masquerading as systemic sclerosis: Two cases demonstrating an important clinical observation. J Rheumatol, 2021, 48 (1), p. 145–146.
  47. TRAINEAU, H., AGGARWAL, R., MONFORT, J. B. et al. Treatment of calcinosis cutis in systemic sclerosis and dermatomyositis: A review of the literature. J Am Acad Dermatol, 2020, 82 (2), p. 317–325.
  48. VALENZUELA, A., CHUNG, L. Subcutaneous calcinosis: Is it different between systemic sclerosis and dermatomyositis? J Scleroderma Relat Disord, 2022, 7 (1), p. 7–23.
  49. WILKERSON, B. W., CRIM, J. R., HUNG, M., LAYFIELD, L. J. Characterization of synovial sarcoma calcification. AJR Am J Roentgenol, 2012, 199 (6), W730–734.
  50. XIE, C. B., KIDACKI, M., RING, N., PANSE, G., LEVENTHAL, J. S. Iatrogenic calcinosis cutis from extravasated phosphate-containing solution treated with topical sodium thiosulfate. JAAD Case Rep, 2021, 17, p. 31–33.
  51. YOSHIKAWA,  M.,  AKASAKA,  E.,  NAKANO,  H., SAWAMURA, D. Dystrophic calcinosis cutis in a patient with cutaneous sarcoidosis in remission. Skin Health Dis, 2022, 3 (1), e174.
  52. ZHU, X., ZHANG, X., YANG, K. Diagnostic aid to subepidermal calcified nodule with dermoscopy and reflectance confocal microscopy: a case report. BMC Pediatr, 2023, 23 (1), p. 102.

Poděkování

Autoři děkují MUDr. Mateji Kuchárovi z Radiodiagnostické kliniky 1. LF UK a VFN za laskavé poskytnutí radiologické dokumentace.

Do redakce došlo dne 8. 3. 2024.

Adresa pro korespondenci:
MUDr. Miroslav Důra, Ph.D.
Dermatovenerologická klinika 1. LF UK a VFN
U Nemocnice 499/2 128 00 Praha 2
e-mail: miroslav.dura@lf1.cuni.cz

Labels
Dermatology & STDs Paediatric dermatology & STDs
19th Congress of Czech and Slovak Dermatovenereologists
Registry of Biological/ Targeted Therapy BIOREP – Summary Report 2023
Cellular Neurothekeoma
Verrucous Annular Plaque on the Trunk
CZECH AND SLOVAK DERMATOLOGY AND VENEREOLOGY
NEWS FROM ABROAD AND CONGRESSES
PERSONAL ANNOUNCEMENTS
FORTHCOMING EVENTS
Article was published in

Czech-Slovak Dermatology

Issue 2
2024 Issue 2
Most read in this issue
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#