#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#
proLékaře.cz / Journals / Czech-Slovak Dermatology / 2024 - 1

Obliterative Vasculopathy in Dermatology

Czech version

Authors: O. Kodet 1,2
Authors‘ workplace: Dermatovenerologická klinika 1. LF UK a VFN, Praha přednosta prof. MUDr. Jiří Štork, CSc. 1;  Anatomický ústav 1. LF UK, Praha přednosta doc. MUDr. Ondřej Naňka, Ph. D. 2
Published in: Čes-slov Derm, 99, 2024, No. 1, p. 3-17
Category: Reviews (Continuing Medical Education)

Overview

Obliterative vasculopathies in dermatology represent a heterogeneous group of diseases with different pathogenesis. These are conditions of non-inflammatory occlusion of the vascular lumen with subsequently induced ischemia of the tissue (skin). In the current nomenclature, we also encounter the term cutaneous microvascular occlusive syndromes, which better characterize the involvement of skin vessels. Diseases that are responsible for occlusive syndromes include platelet pathology, the presence of cryoglobulins, infections affecting the vessel wall, embolisation (e.g. cholesterol), coagulopathy (antiphospholipid syndrome), or diseases accompanying chronic kidney failure (calciphylaxis). Possible skin manifestations include ulceration, necrotic lesions, livedo racemosa, and retiform purpura. The work provides a comprehensive view of the complex issue of these conditions and points to skin manifestations that are considered as manifestations of vasculitis in routine practice.

Keywords:

obliterative vasculopathy – microvascular occlusive syndromes – livedo reticularis – livedo racemosa – retiform purpura – thrombocytopathy – cryoglobulins – calciphylaxis

Sources
  1. ALHANSHANI, A. A. Heparin Induced Thrombocytopenia – Pathophysiology, Diagnosis and Treatment: A Narrative Review. Int J Gen Med., 2023, 16, p. 3947–3953.
  2. AREPALLY, G. M., CINES, D. B. Pathogenesis of heparin-induced thrombocytopenia. Transl Res., 2020, 225, p. 131–140.
  3. AREPALLY, G. M. Heparin-induced thrombocytopenia. Blood, 2017, 129, p. 2864–2872.
  4. BAHRANI, E., PERKINS, I. U., NORTH, J. P. Diagnosing Calciphylaxis: A Review With Emphasis on Histopathology. Am J Dermatopathol., 2020, 42, p. 471–480.
  5. BALIGA, S., YADAV, S., SAGDEO, P. et al. Invasive fungal infection in ANCA-associated vasculitis: Between the Devil and Deep blue sea. Case series and review of the literature. Clin Rheumatol., 2024, 43.
  6. BARBUI, T., FINAZZI, G., FALANGA, A. Myeloproliferative neoplasms and thrombosis. Blood, 2013, 122, p. 2176–2184.
  7. BEKKERS, S., YAZDANI, S. K., VIRMANI, R. et al. Microvascular Obstruction: Underlying Pathophysiology and Clinical Diagnosis. J Am Coll Cardiol., 2010, 55(16), p. 1649–1660.
  8. BETROSIAN, A. P., BERLET, T., AGARWAL, B. Purpura fulminans in sepsis. Am J Med Sci., 2006, 332, p. 339–345.
  9. BLACKMON, J. A., JEFFY, B. G., MALONE, J. C. et al. Oxalosis involving the skin: case report and literature review. Arch Dermatol., 2011, 147, p. 1302–1305.
  10. CALDITO, E. G., CALDITO, N. G., KAUL, S. et al. Erythromelalgia. Part II: Differential diagnoses and management. J Am Acad Dermatol., 2024, 90(3), p. 465–474.
  11. CALDITO, E. G., KAUL, S., CALDITO, N. G. et al. Erythromelalgia. Part I: Pathogenesis, clinical features, evaluation, and complications. J Am Acad Dermatol., 2024, 90(3), p. 453–462.
  12. CERVERA, R., PIETTE, J. C., FONT, J. et al. Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients. Arthritis Rheum., 2002, 46, p. 1019–1027.
  13. COVIC, A., CARUNTU, I. D., BURLACU, A. et al. Therapeutic Potential of Rituximab in Managing Hepatitis C–Associated Cryoglobulinemic Vasculitis: A Systematic Review. J Clin Med., 2023, 12.
  14. CRIADO, P. R., DE SOUZA ESPINELI, D. P. et al. Livedoid vasculopathy and high levels of lipoprotein (a): response to danazol. Dermatol Ther., 2015, 28, p. 248–253.
  15. CRIADO, P. R., RIVITTI, E. A., SOTTO, M. N. et al. Livedoid vasculopathy: an intringuing cutaneous disease. An Bras Dermatol., 2011, 86, p. 961–977.
  16. DEMOULIN, N., AYDIN, S., GILLION, V. et al. Pathophysiology and Management of Hyperoxaluria and Oxalate Nephropathy: A Review. American Journal of Kidney Diseases., 2022, 79, p. 717–727.
  17. DU, V. X., HUSKENS, D., MAAS, C. et al. New insights into the role of erythrocytes in thrombus formation. Semin Thromb Hemost., 2014, 40, p. 72–80.
  18. FEDERICI, A., BUDDE, U., CASTAMAN, G. et al. Current diagnostic and therapeutic approaches to patients with acquired von Willebrand syndrome: a 2013 update. Semin Thromb Hemost., 2013, 39, p. 191–201.
  19. FIERRO, J. J., VELÁSQUEZ-BERRÍO, M., OSPINA, A. et al. The effects of hydroxychloroquine and its promising use in refractory obstetric antiphospholipid syndrome. Rheumatol Int., 2024, 44.
  20. FLÜHLER, C., STINCO, G., DI MEO, N. et al. Malignant form of atrophic papulosis with lethal abdominal involvement. J Eur Acad Dermatol Venereol, 2016, 30, p. 126–128.
  21. FONKOUA, L. K., ZHANG, S., CANTY, E. et al. Purpura fulminans from reduced protein S following cytomegalovirus and varicella infection. Am J Hematol, 2019, 94, p. 491–495.
  22. GARCIA, D., ERKAN, D. Diagnosis and Management of the Antiphospholipid Syndrome. N Engl J Med., 2018, 378, p. 2010–2021.
  23. GASPAR, P., SCIASCIA, S., TEKTONIDOU, M. G. Epidemiology of antiphospholipid syndrome: macroand microvascular manifestations. Rheumatology (Oxford)., 2024, 63, p. 24–36.
  24. GEORGE, J. N., NESTER, C. M. Syndromes of thrombotic microangiopathy. N Engl J Med., 2014, 371, p. 654–666.
  25. GHETIE, D., MEHRABAN, N., SIBLEY, C. H. Cold hard facts of cryoglobulinemia: updates on clinical features and treatment advances. Rheum Dis Clin North Am., 2015, 41, p. 93–108.
  26. GIUGGIOLI, D., MANFREDI, A., LUMETTI, F. et al. Cryoglobulinemic vasculitis and skin ulcers. Our therapeutic strategy and review of the literature. Seminars in Arthritis and Rheumatism, 2015, 44, p. 518–526.
  1. HAMADI, R., SAKR, F., ARIDI, H. et al. Heparin-Induced Thrombocytopenia in Chronic Hemodialysis Patients. Clin Appl Thromb Hemost., 2023, 29.
  2. HELFMAN, T., FALANGA, V. Stanozolol as a novel therapeutic agent in dermatology. J Am Acad Dermatol., 1995, 33, p. 254–258.
  3. HILL, A., DEZERN, A. E., KINOSHITA, T. et al. Paroxysmal nocturnal haemoglobinuria. Nat Rev Dis Primers., 2017, 3.
  4. HOSTETLER, S. G., SOPKOVICH, J., DEAN, S. et al. Warfarin-induced Venous Limb Gangrene. J Clin Aesthet Dermatol., 2012, 5, p. 38.
  5. CHALMERS, E., COOPER, P., FORMAN, K. et al. Purpura fulminans: recognition, diagnosis and management. Arch Dis Child., 2011, 96, p. 1066–1071.
  6. CHANG, J. J., CALCIPHYLAXIS. Diagnosis, Pathogenesis, and Treatment. Adv Skin Wound Care., 2019, 32, p. 205–215.
  7. IMAI, N., ZAMAMI, R., KIMURA, K. Cutaneous cholesterol embolization syndrome. Indian J Dermatol Venereol Leprol., 2015, 81, p. 388.
  8. JAN, Y. K. Advances in Diagnosis and Pathophysiology of Microvascular Dysfunction. Diagnostics, 2022, 12(12), p. 620.
  9. JUCGLA, A., MORESO, F., MUNIESA, C. et al. Cholesterol embolism: still an unrecognized entity with a high mortality rate. J Am Acad Dermatol., 2006, 55, p. 786–793.
  10. KAKAGIA, D. D., PAPANAS, N., KARADIMAS, E. et al. Warfarin-induced skin necrosis. Ann Dermatol., 2014, 26, p. 96–98.
  11. KERK, N., GOERGE, T. Livedoid vasculopathy – current aspects of diagnosis and treatment of cutaneous infarction. J Dtsch Dermatol Ges., 2013, 11, p. 407–411.
  12. KIM, J. S., JANG, J. H., JO, D. Y. et al. Long-Term Efficacy and Safety of Eculizumab in Patients With Paroxysmal Nocturnal Hemoglobinuria and High Disease Burden: Real-World Data From Korea. J Korean Med Sci., 2023, 38, p. 1–12.
  13. KIM, M., KIM, S. S., CHOI, H. I. et al. Cryofibrinogen-associated membranoproliferative glomerulonephritis. Kidney Int., 2023, 104, p. 860.
  14. KNIGHT, J. S., BRANCH, D. W., ORTEL, T. L. Antiphospholipid syndrome: advances in diagnosis, pathogenesis, and management. BMJ, 2023, 380.
  15. KOSTER, A., NAGLER, M., ERDOES, G. et al. Heparin-induced Thrombocytopenia: Perioperative Diagnosis and Management. Anesthesiology, 2022, 136, p. 336–344.
  16. LECKEY, B. D., KHETERPAL, M. K., SELIM, M. A. et al. Cutaneous involvement by T-cell prolymphocytic leukemia presenting as livedoid vasculopathy. J Cutan Pathol., 2021, 48, p. 975–979.
  17. LLAMAS-VELASCO, M., ALEGRÍA, V., SANTOS-BRIZ, Á. et al. Occlusive Nonvasculitic Vasculopathy. American Journal of Dermatopathology., 2017, 39, p. 637–662.
  18. LOBO, FERREIRA, T., ALVES, R., JUDAS, T. et al. Case Report: Marantic endocarditis and paraneoplastic pulmonary embolism. BMJ Case Rep., 2017, 2017.
  19. LV, F. F., LI, M. Y., QU, W. et al. Rivaroxaban for the treatment of heparin-induced thrombocytopenia with thrombosis in a patient undergoing artificial hip arthroplasty: A case report. World J Clin Cases, 2023, 11, p. 6147.
  20. LY, S., RICK, J., GOFF, R. et al. Cutaneous Oxalosis Due to Primary Hyperoxaluria. Am J Dermatopathol., 2022, 44, p. 981–893.
  21. MARESCHAL, A., RAZANAMAHERY, J., AUBIN, F. Malignant Atrophic Papulosis. JAMA Dermatol., 2020, 156, p. 204.
  22. MARLAR, R. A., NEUMANN, A. Neonatal purpura fulminans due to homozygous protein C or protein S deficiencies. Semin Thromb Hemost., 1990, 16, p. 299–309.
  23. MCHUGH, J. W., LEHMAN, J. S., SHAH, A. Pseudomonas aeruginosa-Associated Ecthyma Gangrenosum: A Classic Presentation. Mayo Clin Proc., 2024, 99, p. 336–337.
  24. MICIELI, R., ALAVI, A. Treatment for Livedoid Vasculopathy: A Systematic Review. JAMA Dermatol., 2018, 154, p. 193–202.
  25. MICHAUD, M., POURRAT, J. Cryofibrinogenemia. J Clin Rheumatol., 2013, 19, p. 142–148.
  26. MONDAL, S., KUMAR, S. S., ILIYAS, M. Atrial myxoma presenting as bilateral cerebellar infarct and mitral obstruction. Acta Cardiol., 2023, 78, p. 1153–1155.
  27. MORÁN-MARIÑOS,  C.,  CORCUERA-CIUDAD,  R., VELÁSQUEZ-RIMACHI, V. et al. Systematic review of warfarin-induced skin necrosis case reports and secondary analysis of factors associated with mortality. Int J Clin Pract., 2021, 75.
  28. NACIRI, BENNANI, H., BANZA, A. T., TERREC, F. et al. Cryoglobulinemia and double-filtration plasmapheresis: Personal experience and literature review. Ther Apher Dial., 2023, 27, p. 159–169.
  29. NIGWEKAR, S. U., THADHANI, R., BRANDENBURG, V. M. Calciphylaxis. N Engl J Med., 2018, 378, p. 1704–1714.
  30. NUNZIE, E., CABRERA, L. V. O., MONCAYO, F. M. M. et al. Lucio Leprosy with Lucio’s phenomenon, digital gangrene and anticardiolipin antibodies. Lepr Rev., 2014, 85, p. 194–200.
  31. OKU, K., NAKAMURA, H., KONO, M. et al. Complement and thrombosis in the antiphospholipid syndrome. Autoimmun Rev., 2016, 15, p. 1001–1004.
  32. PAYET, J., LIVARTOWSKI, J., KAVIAN, N. et al. Type I cryoglobulinemia in multiple myeloma, a rare entity: analysis of clinical and biological characteristics of seven cases and review of the literature. Leuk Lymphoma, 2013, 54, p. 767–777.
  33. PENNINGTON, M., YEAGER, J., SKELTON, H. et al. Cholesterol embolization syndrome: cutaneous histopathological features and the variable onset of symptoms in patients with different risk factors. Br J Dermatol., 2002, 146, p. 511–517.
  1. PRICE, V. E., LEDINGHAM, D. L., KRÜMPEL, A. et al. Diagnosis and management of neonatal purpura fulminans. Semin Fetal Neonatal Med., 2011, 16, p. 318–322.
  2. REAGIN, H., MARKS, E., WEIS, S. et al. Livedoid Vasculopathy Presenting in a Patient With Sickle Cell Disease. Am J Dermatopathol., 2018, 40, p. 682–685.
  3. REISCH, N., ROEHNISCH, T., SADEGHI, M. et al. AML M1 presenting with recurrent acute large arterial vessel thromboembolism. Leuk Res., 2007, 31, p. 869–871.
  4. RICK, J., RRAPI, R., CHAND, S. et al. Calciphylaxis: Treatment and outlook-CME part II. J Am Acad Dermatol., 2022, 86, p. 985–992.
  5. RICK, J., STROWD, L., PASIEKA, H. B. et al. Calciphylaxis: Part I. Diagnosis and pathology. J Am Acad Dermatol., 2022, 86, p. 973–982.
  6. RUIZ-IRASTORZA, G., CROWTHER, M., BRANCH, W. et al. Antiphospholipid syndrome. Lancet., 2010, 376, p. 1498–1509.
  7. SAADOUN, D., ELALAMY, I., GHILLANI-DALBIN, P. et al. Cryofibrinogenemia: New Insights into Clinical and Pathogenic Features. American Journal of Medicine., 2009, 122, p. 1128–1135.
  8. SAMANTA, D., COBB, S., ARYA, K. et al. Syndrome: A Comprehensive Overview. J Stroke Cerebrovasc Dis., 2019, 28, p. 2098–2108.
  9. SANTIAGO, M. B., MELO, B. S. Cryofibrinogenemia: What Rheumatologists Should Know. Curr Rheumatol Rev., 2022, 18, p. 186–194.
  10. SONG, J. K., JUNG, S. S., KANG, S. W. Two cases of eosinophilic vasculitis with thrombosis. Rheumatol Int., 2008, 28(37), p. 1–4.
  11. SPERNOVASILIS,  N.,  PSICHOGIOU,  M.,  POULAKOU, G. Skin manifestations of Pseudomonas aeruginosa infections. Curr Opin Infect Dis., 2021, 34, p. 72–79.
  12. STARMANS, N. L. P., ZOETEMEYER, S., VAN DIJK, M. R. et al. The diagnostic value of skin biopsies in Sneddon syndrome. PLoS One, 2021, 16.
  13. TEFFERI, A., BARBUI, T. Polycythemia vera and essential thrombocythemia: 2021 update on diagnosis, risk-stratification and management. Am J Hematol., 2020, 95, p. 1599–1613.
  14. TERRIER, B., CACOUB, P. Cryoglobulinemia vasculitis: An update. Curr Opin Rheumatol., 2013, 25, p. 10–18.
  15. THEODORIDIS, A., KONSTANTINIDOU, A., MAKRANTONAKI, E. et. al. Malignant and benign forms of atrophic papulosis (Köhlmeier-Degos disease): systemic involvement determines the prognosis. Br J Dermatol., 2014, 170, p. 110–115.
  16. THERON, A., DAUTREMAY, O., BOISSIER, E. et al. Idiopathic purpura fulminans associated with anti-protein S antibodies in children: a multicenter case series and systematic review. Blood Adv., 2022, 6, p. 495–502.
  17. WEISER, J. A., SCULLY, B. E., BULMAN, W. A. et. al. Periumbilical parasitic thumbprint purpura: strongyloides hyperinfection syndrome acquired from a cadaveric renal transplant. Transpl Infect Dis., 2011, 13, p. 58–62.
  18. YUTANI, C., NAGANO, T., KOMATSU, S., KODAMA, K. Visible-free cholesterol crystal emboli adjacent to microinfarcts in myocardial capillaries and arterioles on H&E-stained frozen sections of an autopsied patient. BMJ Case Rep., 2018, p. 1–3.
  19. ZHAO, H., SHATTIL, S. Cutaneous thrombosis in PNH. Blood, 2013, 122, p. 3249.

Do redakce došlo dne 19. 2. 2024.

Adresa pro korespondenci:
doc. MUDr. Ondřej Kodet, Ph.D.
Dermatovenerologická klinika 1. LF UK a VFN
U Nemocnice 499/2 128 00 Praha 2
e-mail: ondrej.kodet@lf1.cuni.cz

Labels
Dermatology & STDs Paediatric dermatology & STDs
Cutaneous Endometriosis in the Umbilicus
Induced Dermatitis/Vasculitis of the Lower Legs
Numerous Tiny Brownish Papules on the Forearms
Zápis ze schůze výboru ČDS konané dne 24. 11. 2023
Trendy v léčbě atopického ekzému z německých Doporučených postupů 2023
FORTHCOMING EVENTS
AUTHOR AND REFEREE GUIDELINES
Article was published in

Czech-Slovak Dermatology

Issue 1
2024 Issue 1
Most read in this issue
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#