Palmo-plantar Erythrodysesthesia caused by Liposome-encapsulated Doxorubicin

Overview

Palmo-plantar erythrodysesthesia (PPE) is a relatively frequent manifestation of the side-effectsof chemotherapy in the skin. It has a clear-out clinical picture, non-specific histology and unclearpathogenesis. Its course in patients often calls for modification and sometimes interruption ofotherwise effective chemotherapy. There is no specific treatment, however, there has been describedthe possible application of certain drugs in cases of chemotherapeutics with which the risk of PPEis most often connected (doxorubicin, cytarabin, docetaxel, fluorouracil). The author describesa clinical case of PPE upon application of liposome-encapsulated doxorubicin in a patient sufferingfrom ovarial carcinoma.

Key words:
chemotherapy - doxorubicin - side-effects - erythrodysesthesia