Dermoepidermal Junction and Target Antigens in Bullous Pemphigoid

Czech version

Authors: H. Jedličková
Authors‘ workplace: I. dermatovenerologická klinika, FN U sv. Anny v Brněpřednostka doc. MUDr. V. Semrádová, CSc.
Published in: Čes-slov Derm, , 2000, No. 2, p. 80-84
Category:

Overview

The aim of this review is to summarize recent knowledge about the structure and components ofdermoepidermal junction and about the role of these structures in pathogenesis of genetic andacquired blistering diseases localized to the junction zone. Hemidesmosome is the crucial structurethat contributes to the attachment of keratinocytes to the dermis. The hemidesmosome moleculesmediate signals co-ordinating the attachment of cells, their survival, growth and migration. Hemi-desmosome is composed of four known molecules - bullous pemphigoid antigens BP1 and BP2, plectinand a6b4 integrin. Antibodies against hemidesmosome and other components of dermoepidermaljunction cause autoimmune blistering diseases. Genetic mutations of these molecules result ingenetic blistering diseases.

Key words:
hemidesmosome - basement membrane - bullous pemphigoid - epidermolysis

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Article was published in

Czech-Slovak Dermatology

2000 Issue 2