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Follicle-stimulating hormone and its effects on bone and cartilage


Authors: K. Brábníková Marešová
Authors‘ workplace: Revmatologický ústav Praha
Published in: Čes. Revmatol., 30, 2022, No. 4, p. 166-170.
Category: Review Article

Overview

The prevalence of osteoporosis and osteoarthritis increases during menopause and is associated with changes in serum levels of estrogen and follicle-stimulating hormone (FSH). The progression of osteoporosis and osteoarthritis in postmenopausal women is effectively prevented by estrogen treatment, possible side effects of which, however, discourage the wider use of hormone replacement therapy for the prevention of osteoporosis and osteoarthritis. Follicle-stimulating hormone can influence bone remodeling and cartilage metabolism independently of estrogens. This is how FSH was applied in the regulation of bone remodeling in women with FSH receptor polymorphism (FSHR). A receptor for FSH has been demonstrated in osteoclasts. Blocking FSHR can suppress bone resorption and increase vertebral bone mass in ovariectomized mice. In articular cartilage, FSH binds to a specific receptor and suppresses the synthesis of extracellular matrix proteins. This effect can be blocked. The use of experimental and clinical knowledge on FSH can represent another direction in the prevention of postmenopausal osteoporosis and osteoarthritis.

Keywords:

cartilage – bone – menopause – FSH – receptor for FSH


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