Vplyv spôsobu pôrodu na epigenetické zmeny u novorodencov a ich zdravotné následky
Authors:
Zuzana Turcsányiová; Petra Gašparová; Zuzana Ballová; Erik Dosedla
Authors‘ workplace:
Department of Gynaecology and Obstetrics, Faculty of Medicine, Pavol Jozef Safarik University in Košice, Hospital AGEL Košice-Šaca Inc., Slovak Republic
Published in:
Ceska Gynekol 2024; 89(4): 329-334
Category:
doi:
https://doi.org/10.48095/cccg2024329
Overview
V posledných desaťročiach sme zaznamenali výrazný nárast počtu cisárskych rezov. Hoci je pôrod cisárskym rezom život zachraňujúci, je spojený so zvýšeným rizikom nepriaznivých zdravotných následkov u novorodencov, vrátane respiračných a atopických ochorení, obezity, cukrovky a závažných autoimunitných ochorení. Presné mechanizmy, ktoré sú základom týchto spojitostí zostávajú nepochopené; epigenetické modifikácie sa však ukázali ako pravdepodobný molekulárny základ spájajúci perinatálne faktory s budúcou náchylnosťou na ochorenie. Tento prehľad spája súčasnú literatúru a odhaľuje, že spôsob pôrodu môže ovplyvniť epigenetické markery u novorodencov, predovšetkým prostredníctvom zmien globálnej metylácie DNA a génovo špecifických metylačných vzorcov.
Klíčová slova:
cisársky rez – metylácia DNA – epigenetika
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Paediatric gynaecology Gynaecology and obstetrics Reproduction medicineArticle was published in
Czech Gynaecology
2024 Issue 4
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