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Faktory spojené s mateřskou úmrtností covid-19 pozitivních pacientek – průřezová studie z indonéské referenční nemocnice pro covid-19


Authors: S. Azizah;  A. P. Mustika;  N. Widjaya;  R. Irwinda;  A. K. Harzif;  T. Priyatini;  M. Maidarti;  M. A. F. Dilmy;  V. Silvana;  C. Teguh;  A. T. Rivai;  Z. Djuliannisaa;  V. A. F. Nasution;  D. L. Darmestari;  R. Sukmadewanti;  Z. T. Cahyaningrum;  E. S. N. Amalia;  M. Jamilah
Authors‘ workplace: Universitas Indonesia Hospital, Indonesia
Published in: Ceska Gynekol 2023; 88(5): 334-346
Category: Original Article
doi: https://doi.org/10.48095/cccg2023334

Overview

Východiska: Pandemie covidu-19 může způsobit závažné klinické projevy u zranitelné populace, jako jsou těhotné ženy. Podle Indonéské asociace porodnictví a gynekologie (POGI) dosáhl počet úmrtí matek v důsledku covidu-19 od dubna 2020 do dubna 2021 3 % a od vzniku delta varianty covidu-19 vzrostl na 9 %. Tento výzkum byl navržen tak, aby identifikoval faktory spojené s úmrtností těhotných žen s covidem-19. Materiál a metody: Jednalo se o průřezovou studii využívající sekundární data shromážděná od června 2020 do srpna 2021. Studie byla provedena v Universitas Indonesia Hospital, národní referenční nemocnici pro covid-19. Hodnotila se charakteristika pacientky, profil těhotenství, komorbidity, laboratorní výsledky, RTG vyšetření hrudníku, možnosti léčby a závažnost symptomů. Kromě toho byla provedena bivariační analýza dat pomocí SPSS. Výsledky: Ze 114 výzkumných subjektů sedm pacientek (6,1 %) zemřelo a 107 pacientek (93,9 %) přežilo. Riziko úmrtnosti významně (p < 0,05) souviselo s věkem pacientky, délkou hospitalizace, gestačním věkem, závažností covidu-19, hladinou hemoglobinu, počtem leukocytů, počtem krevních destiček, lymfocytů, hladinami D-dimerů, C-reaktivním proteinem, transaminázovými enzymy, močovinou, kreatininem, eGFR, sodíkem, draslíkem a prokalcitoninem. Kromě toho byly také prokázány významné rozdíly (p < 0,05) související s úmrtností matek v přítomnosti komorbidit (diabetes 2. typu, městnavé srdeční selhání, ischemická choroba srdeční/akutní koronární syndrom a infekce močových cest) a při užívaní steroidů a tocilizumabu. Závěr: S úmrtností těhotných žen na covid-19 jsou významně spojeny různé faktory. Tato studie může tvořit základ pro další studie s větším počtem subjektů, modifikovat hodnocení a management těhotných žen s covidem-19 a následně snížit úmrtnost těhotných žen.

Klíčová slova:

mortalita – těhotenství – COVID-19 – související faktory


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Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine

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Czech Gynaecology

Issue 5

2023 Issue 5

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