Effect of Vaginal Estriol on Urogenital Symptomsin Postmenopausal Women

Overview

Objective:
The objective of this work was to evaluate the effi cacy, acceptability and safety of thevaginal estriol on symptoms in postmenopausal women with urogenital atrophy.Design: Prospective clinical study.Setting: Department of Obstetrics and Gynecology of the 1st Medical Faculty and General FacultyHospital, Prague.Methods: We included in our study 68 postmenopausal women with proved urogenital symptomsof the atrophic genitourinary tract. We administration them two years vaginal estriol 0.5 mg daily,later 1-2 times a week and than detected subjective and objective changes in their low urinarytract and vagina. These women had a normal biochemistry, uterus, mammary and bone density.These parameters were evaluated before starting the treatment and after 3 and 6 month. Thestatistical signifi cance of the phenomen was evaluated by exact t-test.Results: Statistically signifi cant positive differences and remission were observed in all symptomsand recurrent infection of the atrophical urogenital tissues.The fi rst satisfaction was after 3th month and the best after 6th month of this therapy, and inthe end of this study (24 month) it was the same. We recorded no difference in other monitoredparameters (endometrium, biochemistry, mammography, densitometry, blood pressure, weight)and compliance was satisfactory (85% after 6 months). In the 6 month profi le of estriol we founda signifi cant decrease of the Kupperman index and the Menopause rating scale.Conclusion: Administration of vaginal estriol is an advisable choice for every postmenopausalwoman with the genitourinary problems (urgency, pollakisuria, dysuria, nycturia, recurrent infectionof the low urinary tract). It has very good clinical effects and minimum side effects.

Key words:
estriol, genitourinary atrophy, urgency