Metalloproteinases Matrix and MenstruationReview

Czech version

Authors: R. Pilka; P. Hrachovec
Authors‘ workplace: Gynekologicko-porodnická klinika, LF a FN UP Olomouc, přednosta prof. MUDr. M. Kudela, CSc.
Published in: Ceska Gynekol 2003; (1): 36-40
Category:

Overview

During every menstrual cycle the extracellular matrix in the uterus undergoes dramatic changesassociated with release and shedding of the endometrium. Classical investigations made in monkeysassumed that menstruation is caused by vasoconstriction, hypoxia and subsequent necrosis.More recent work indicates the importance of the system of matrix metalloproteinases (MMP) forthe extracellular architecture of the endometrium. The submitted paper presents a review ofcrucial characteristics of the MMP system and its importance for cyclic transformation of theendometrium during the menstrual cycle. From the review it is apparent that impairment of theMMP equilibrium and its tissue inhibitors are an essential prerequisite of tissue degradation andmenstruation. MMP activation is requlated by hypoxia, a drop progesterone and paracrine factorsreleased by epithelial, stromal and migratory cells.

Key words:
metalloproteinase, endometrium, menstrual cycle

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