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proLékaře.cz / Journals / Czech Dental Journal / 2024 - 3

Proliferative verrucous leukoplakia: retrospektive study

Czech version

Authors: N. Molnárová 1,2;  J. Liška 1,2;  V. Lišková 1,2
Authors‘ workplace: Stomatologická klinika, Fakultní nemocnice Plzeň 1;  Stomatologická klinika, Lékařská fakulta v Plzni, Univerzita Karlova 2
Published in: Česká stomatologie / Praktické zubní lékařství, ročník 124, 2024, 3, s. 59-68
Category: Original Article – Retrospective Essay
doi: https://doi.org/10.51479/cspzl.2024.003

Overview

Introduction and aim: Retrospective study focused on clinically and biopsy-proven cases of proliferative verrucous leukoplakia (PVL). The aim of the work is to point out the necessity of correlation of oral manifestations of PVL with clinical and radiological examination of the periodontium.

Methods: The study evaluated the process of PVL disease in 53 patients followed between 1994 and 2024 at the Oral Medicine Department, Dentistry Clinic, University hospital in Pilsen. Apart from anamnestic-pathological correlations, also the aspects of coincidence with other lesions of the oral mucosa, the formation of dysplasia during this aggressive disease and the frequency of malignant transformation were assessed. The mucosal manifestation of the disease was regularly compared to the clinical and radiological state of the periodontium.

Results: During dispensary, recurrence occurred in 56% of cases (n = 30/53) and transformation into oral squamous cell carcinoma (OSCC) in 38% of patients (n = 20/53). Oncological recurrence was in five cases (9%). The majority of patients with malignant transformation were women with 70% (n = 14/20).

Conclusion: In contrary to other diseases of the oral mucosa, taking OPG or CBCT images is diagnostically more beneficial within the PVL dispensary. In several patients with lesions in the area of the alveolar mucosa and gingiva, there is significant resorption of the alveolar bone in the corresponding locations in the case of an ongoing malignant transformation. Malignant transformation of PVL is indeed high, up to 38% in our group. Due to the risk of diagnostic confusion of oral lichen planus and chronic hyperplastic candidiasis with incipient PVL, it is necessary to tighten the dispensary rules for these cases as well.

Keywords:

proliferative verrucous leukoplakia, oral potentially malignant disorders, malignant transformation, oral squamous cell carcinoma

Sources
  1. Silk H. Diseases of the mouth. Prim Care. 2014; 41(1):75–90. doi: 10.1016/j.pop.2013.10.011
  2. Abidullah M, Kiran G, Gaddikeri K, Raghoji S, Ravishankar TS. Leuloplakia – review of a potentially malignant disorder. J Clin Diagn Res. 2014;8(8): ZE01–4. doi: 10.7860/JCDR/2014/10214.4677
  3. Warnakulasuriya S. Oral potentially malignant disorders: A comprehensive review on clinical aspects and management. Oral Oncol. 2020; 102: 104550. doi: 10.1016/j.oraloncology.2019.104550
  4. Speight PM, Khurram SA, Kujan O. Oral potentially malignant disorders: risk of progression to malignancy. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018; 125(6): 612–627. doi: 10.1016/j.oooo.2017.12.011
  5. Yang EC, Tan MT, Schwarz RA, Richards-Kortum RR, Gillenwater AM, Vigneswaran N. Noninvasive diagnostic adjuncts for the evaluation of potentially premalignant oral epithelial lesions: current limitations and future directions. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018; 125(6): 670–681. doi: 10.1016/j.oooo.2018.02.020
  6. Yang X, Chen F, Shen X, Zhang C, Liu W. Profiling risk factors of micro-invasive carcinoma within oral potentially malignant disorders: a cross-sectional study. Clin Oral Investig. 2020; 24(10): 3715–3720. doi: 10.1007/s00784-020-03568-y
  7. Warnakulasuriya S, Kujan O, Aguirre-Urizar JM, Bagan JV, González-Moles MÁ, Kerr AR, Lodi G, Mello FW, Monteiro L, Ogden GR, Sloan P, Johnson NW. Oral potentially malignant disorders: A consensus report from an international seminar on nomenclature and classification, convened by the WHO Collaborating Centre for Oral Cancer. Oral Dis. 2021; 27(8): 1862–1880. doi: 10.1111/odi.13704
  8. Warnakulasuriya S, Johnson NW, van der Waal I. Nomenclature and classification of potentially malignant disorders of the oral mucosa. J Oral Pathol Med. 2007; 36(10): 575–580. doi: 10.1111/j.1600-0714.2007.00582.x
  9. Kumari P, Debta P, Dixit A. Oral potentially malignant disorders: etiology, pathogenesis, and transformation into oral cancer. Front Pharmacol. 2022; 13: 825266. doi: 10.3389/fphar.2022.825266
  10. Ranganathan K, Kavitha L. Oral epithelial dysplasia: Classifications and clinical relevance in risk assessment of oral potentially malignant disorders. J Oral Maxillofac Pathol. 2019; 23(1): 19–27. doi: 10.4103/jomfp.JOMFP_13_19
  11. Melrose RJ. Premalignant oral mucosal diseases. J Calif Dent Assoc. 2001; 29(8): 593–600. PMID: 11577670.
  12. Campisi G, Giovannelli L, Ammatuna P, Capra G, Colella G, Di Liberto C, Gandolfo S, Pentenero M, Carrozzo M, Serpico R, D'Angelo M. Proliferative verrucous vs conventional leukoplakia: no significantly increased risk of HPV infection. Oral Oncol. 2004; 40(8): 835–840. doi: 10.1016/j.oraloncology.2004.02.007.
  13. Capella DL, Gonçalves JM, Abrantes AAA, Grando LJ, Daniel FI.Proliferative verrucous leukoplakia: diagnosis, management and current advances. Braz J Otorhinolaryngol. 2017; 83(5): 585–593.doi: 10.1016/j.bjorl.2016.12.005
  14. Thompson LDR, Fitzpatrick SG, Müller S, Eisenberg E, Upadhyaya JD, Lingen MW, et al. Proliferative Verrucous Leukoplakia: An Expert Consensus Guideline for Standardized Assessment and Reporting. Head Neck Pathol. 2021; 15(2):572–587. doi: 10.1007/s12105-020-01262-9
  15. Munde A, Karle R. Proliferative verrucous leukoplakia: An update. J Cancer Res Ther. 2016; 12(2): 469–473. doi: 10.4103/0973-1482.151443
  16. Palaia G, Bellisario A, Pampena R,Pippi R, Romeo U. Oral proliferative verrucous leukoplakia: progression to malignancy and clinical implications. systematic review and metaanalysis. Cancers (Basel). 2021;13(16): 4085. doi: 10.3390/cancers13164085
  17. Hansen LS, Olson JA, Silverman S Jr. Proliferative verrucous leukoplakia. A longterm study of thirty patients. Oral Surg Oral Med Oral Pathol. 1985; 60(3): 285–298. doi: 10.1016/0030-4220(85)90313-5
  18. Silverman S Jr, Gorsky M. Proliferative verrucous leukoplakia: a followup study of 54 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997; 84(2): 154–157. doi: 10.1016/s1079-2104(97)90062-7
  19. Cerero-Lapiedra R, Baladé-Martínez D, Moreno-López LA, Esparza-Gómez G, Bagán JV. Proliferative verrucous leukoplakia: a proposal for diagnostic criteria. Med Oral Patol Oral Cir Bucal. 2010; 15(6): e839–e845. PMID: 20173704.
  20. González-Moles MÁ,Warnakulasuriya S, Ramos-García P. Prognosis parameters of oral carcinomas developed in proliferative verrucous leukoplakia: a systematic review and metaanalysis. Cancers (Basel). 2021; 13(19): 4843. doi: 10.3390/cancers13194843
  21. Cabay RJ, Morton TH Jr, Epstein JB. Proliferative verrucous leukoplakia and its progression to oral carcinoma: a review of the literature. J Oral Pathol Med. 2007; 36(5): 255–261. doi: 10.1111/j.1600-0714.2007.00506.x
  22. Alabdulaaly L, Villa A, Chen T, Kerr A, Ross N, Abreu Alves F, Guollo A, Woo SB. Characterization of initial/early histologic features of proliferative leukoplakia and correlation with malignant transformation: a multicenter study. Mod Pathol. 2022; 35(8): 1034–1044. doi: 10.1038/s41379-022-01021-x
  23. Müller S.Oral epithelial dysplasia, atypical verrucous lesions and oral potentially malignant disorders: focus on histopathology.Oral Surg Oral Med Oral Pathol Oral Radiol. 2018; 125(6): 591–602.doi: 10.1016/j.oooo.2018.02.012
  24. Li CC, Almazrooa S, Carvo I, Salcines A, Woo SB. Architectural alterations in oral epithelial dysplasia are similar in unifocal and oroliferative leukoplakia. Head Neck Pathol. 2021; 15(2): 443-460. doi: 10.1007/s12105-020-01216-1
  25. Warnakulasuriya S, Johnson NW, van der Waal I. Nomenclature and classification of potentially malignant disorders of the oral mucosa. J Oral Pathol Med. 2007; 36(10): 575–580. doi: 10.1111/j.1600-0714.2007.00582.x
  26. Warnakulasuriya S. Clinical features and presentation of oral potentially malignant disorders. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018; 125(6): 582–590. doi: 10.1016/j.oooo.2018.03.011
  27. Warnakulasuriya S. Oral potentially malignant disorders: A comprehensive review on clinical aspects and management. Oral Oncol. 2020; 102: 104550.doi: 10.1016/j.oraloncology.2019.104550
  28. Irani S. Pre-cancerous lesions in the oral and maxillofacial region: a literature review with special focus on etiopathogenesis. Iran J Pathol. 2016; 11(4): 303–322. PMID: 28855922; PMCID: PMC5563928.
  29. Ghosh S, Pal S, Ghatak S, Saha S, Biswas S, Srivastava P.A clinicopathologic and epidemiologic study of chronic white lesions in the oral mucosa. Ear Nose Throat J. 2017; 96(8): E13-E17. doi: 10.1177/014556131709600804
  30. Awadallah M, Idle M, Patel K, Kademani D. Management update of potentially premalignant oral epithelial lesions.Oral Surg Oral Med Oral Pathol Oral Radiol. 2018; 125(6): 628–636. doi: 10.1016/j.oooo.2018.03.010
  31. van der Waal I.Historical perspective and nomenclature of potentially malignant or potentially premalignant oral epithelial lesions with emphasis on leukoplakia-some suggestions for modifications. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018; 125(6): 577–581. doi: 10.1016/j.oooo.2017.11.023
  32. Villa A, Celentano A, Glurich I, Borgnakke WS, Jensen SB, Peterson DE, Delli K, Ojeda D, Vissink A, Farah CS. World Workshop on Oral Medicine VII: Prognostic biomarkers in oral leukoplakia: A systematic review of longitudinal studies. Oral Dis. 2019; 25(Suppl 1): 64-78. doi: 10.1111/odi.13087
  33. Ranganathan K, Kavitha L. Oral epithelial dysplasia: Classifications and clinical relevance in risk assessment of oral potentially malignant disorders. J Oral Maxillofac Pathol. 2019; 23(1): 19–27. doi: 10.4103/jomfp.JOMFP_13_19
  34. Bates T, Richards A, Pring, M. Oral potentially malignant disorders: a practical review for the diagnostic pathologist. Diagnostic Histopathol, 2003; 29(4): 208–224. Dostupné z: https://doi. org/10.1016/j.mpdhp.2023.01.004
  35. Porter S, Gueiros LA, Leão JC, Fedele S. Risk factors and etiopathogenesis of potentially premalignant oral epithelial lesions. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018; 125(6): 603–611. doi: 10.1016/j. oooo.2018.03.008
  36. Maver-Biscanin M, Mravak-Stipetic M, Jerolimov V, Biscanin A. Fungicidal effect of diode laser irradiation in patients with denture stomatitis. Lasers Surg Med. 2004; 35(4): 259–262. doi: 10.1002/lsm.20075
  37. Ozkan L, Cetiner S, Sanlidag T. Effect of Er,Cr:YSGG laser irradiation with radial firing tips on Candida albicans in experimentally infected root canals. Biomed Res Int 2014; 2014: 938245. doi: 10.1155/2014/938245
  38. Matulić N, Bago I, Sušić M, Gjorgievska E, Kotarac Knežević A, Gabrić D. Comparison of Er:YAG and Er,Cr:YSGG laser in the treatment of oral leukoplakia lesions refractory to the local retinoid therapy. Photobiomodul Photomed Laser Surg. 2019; 37(6): 362–368. doi: 10.1089/photob.2018.4560
  39. Li B, Fang X, Hu X, Hua H, Wei P. Successful treatment of chronic hyperplastic candidiasis with 5-aminolevulinic acid photodynamic therapy: A case report. Photodiagnosis Photodyn Ther. 2022; 37: 102633. doi: 10.1016/j.pdpdt.2021.102633
  40. Zhang W, Wu S, Wang X, Wei P, Yan Z. Combination treatment with photodynamic therapy and laser therapy in chronic hyperplastic candidiasis: A case report. Photodiagnosis Photodyn Ther. 2022; 38: 102819. doi: 10.1016/j.pdpdt.2022.102819
  41. AlGhamdi AS, Qamar Z, AlSheikh R, Al Hinai MTA, Abdul NS, Aljoghaiman EA, Ali S. Clinical efficacy of 5-aminolevulinic acidmediated photodynamic therapy versus topical antifungal agent and surgical excision for the treatment of hyperplastic candidiasis. Photodiagnosis Photodyn Ther. 2023; 41: 103258. doi: 10.1016/j.pdpdt.2022.103258
Labels
Maxillofacial surgery Orthodontics Dental medicine
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