Možnosti využití komplexní farmaceutické kompozice pro farmakologickou korekci metabolického syndromu
Authors:
Kateryna Kalko 1; Nadia Dukhnich 2; Oksana Mishchenko 2; Viktor Khomenko 3; Olena Toziuk 4
Authors‘ workplace:
Department of Pharmacology and Drug Technology of I. I. Mechnikov Odesa National University
1; Department of Clinical Pharmacology of the National University of Pharmac, Kharkiv, Ukraine
2; Department of Pharmacology and Pharmacy of the Donetsk National Medical University, Lyman, Ukraine
3; Department of Pharmacy, National Pirogov Memorial Medical University, Vinnytsya, Ukraine
4
Published in:
Čes. slov. Farm., 2023; 72, 287-296
Category:
Original Articles
doi:
https://doi.org/10.5817/CSF2023-6-287
Overview
Metabolický syndrom (MetS) je symptomatický komplex charakterizovaný inzulinovou rezistencí, poruchou prooxidačně-antioxidační rovnováhy organismu s rozvojem subchronického zánětu a dyslipidemií. Cílem studie je prozkoumat vlivkomplexní farmaceutické kompozice (CPC) (antioxidanty a metabolitotropní látky), která se v lékařské praxi na Ukrajině široce používá jako multivitaminový komplex, na experimentální metabolický syndrom u potkanů. Byl hodnocen vliv CPC na korekci experimentálního MetS u potkanů, vyvolaného vysokým obsahem sacharidů a tuků ve stravě. MetS u potkanů byl charakterizován snížením citlivosti buněk na inzulin, zvýšeným obsahem glukózy a porušením její utilizace, a prooxidačně-antioxidační dysbalancí. Výsledky provedených studií naznačují pozitivní vliv CPC, který obsahuje etylestery omega-3 kyselin, vitamin E, koenzym Q10, zinek, vitamin A, biotin a selen, na citlivost buněk k inzulinu, utilizaci glukózy, trvání hyperglykémie a ukazatele oxidačních procesů volných radikálů a antioxidačníchobranných systémů u potkanů s experimentálním MetS. Tyto výsledky dokazují možnost využití CPC k korekci metabolického syndromu.
Klíčová slova:
metabolický syndrom – hyperglykemie – citlivost buněk na inzulin – prooxidačně-antioxidační rovnováha
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Czech and Slovak Pharmacy
2023 Issue 6
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