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Inflammatory bowel disease: factors involved in pathogenesis


Authors: Boris Dudík;  Hana Kiňová Sepová;  Andrea Bilková
Published in: Čes. slov. Farm., 2018; 67, 95-100
Category: Review Articles

Overview

The incidence of inflammatory bowel disease (IBD) in developed countries increases every year. The aetiology is still not completely understood and its clarification is a key prerequisite for effective prophylaxis and therapy. IBD is most-likely caused by a combination of several factors: environmental, genetic, immunological, and disruption of intestinal microbiota composition – dysbiosis. “Westernization” of lifestyle and urbanization seem to be among the most serious environmental factors. The pathogenesis is also influenced by the imbalance between the TH1 and TH2 cellular response and the expression of genes involved in T cell response and immunodeficiency. Last but not least, the worldwide overuse of antimicrobial drugs depletes the microbiome, which has a direct impact on the development of the dysbiosis. The subject of this review is a detailed characterization of the above-mentioned factors involved in the onset and development of IBD.

Key words:

gut microbiota • inflammatory bowel disease • immunopathogenesis • dysbiosis


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