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Formulation of salvia-containing gels


Authors: Zuzana Vitková;  Petra Herdová;  Alexandra Kodadová;  Jana Šeligová;  Daniel Grančai;  Dominika Poláková
Published in: Čes. slov. Farm., 2012; 61, 169-171
Category: Short Article

Došlo 20. dubna 2012 / Přijato 25. května 2012

Overview

The trend during the past years is to prefer natural drugs to synthetically prepared medicines. Due to its important antiphlogistic, antiseptic and antihidrotic effects, Salvia officinalis L. has a wide use in medicine, pharmacy and cosmetics in various dosage forms. The aim of this research was the formulation of Salvia officinalis L. in the form of a tincture to hydrogels. Gels were parallelly prepared on the basis of the natural polymer chitosan and the synthetic polymer Carbopol® 940. The evaluation was focused on the influence of the anionic polymer and the cationic polymer in different concentrations on hydrogel flow properties. Glycerol functioning as a humectant was used in various percentage ratios. On the basis of the determination of rheological parameters and flow curves lapses the most suitable hydrogel from the application point of view was selected.

Keywords:
hydrogel, Salvia officinalis L., chitosan, Carbopol® 940, rheological parameters


Sources

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2. Dash M., Chiellini F., Ottenbrite R. M., Chiellini E. Chitosan – a versatile semi-synthetic polymer in biomedical applications. Progress in Polymer Science. 2011; 36(8), 981–1014.

3. Čižmárik J., Matušová D., Vitková Z., Brázdovičová B., Herdová P. Štúdium lokálnych anestetík. Časť: 192. Formulácia lidokaínu do gélov s protizápalovým účinkom. Čes. a slov. Farm. 2010; 59, 277–279.

Labels
Pharmacy Clinical pharmacology
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