Studies of local anaesthetics – Part 197
Effect of xylitol on pharmaceutical availability of lidocaine and flow properties of hydrogels

Czech version

Authors: Zuzana Vitková; Petra Herdová; Jozef Čižmárik; Daniel Grančai; Lukáš Benč
Authors‘ workplace: Univerzita Komenského v Bratislave, Farmaceutická fakulta Katedra galenickej farmácie, Katedra farmaceutickej chémie, Katedra farmakognózie a botaniky
Published in: Čes. slov. Farm., 2012; 61, 130-132
Category: Short News

Overview

The paper examines the formulation of hydrogel on the base of a synthetic polymer containing a local anaesthetic and a mass-produced drug in the form of a solution with an antiphlogistic effect. It aimed to prepare a hydrogel of a suitable composition with suitable flow properties and drug release, the active ingredient being lidocaine hydrochloride. Besides the role of a synthetic polymer which ensures that the active ingredient remains at the affected site, an important role in the formulation is played by the presence of an artificial sweetener, which to a great extent as a taste correcting agent of the unpleasant taste of the active ingredient influences the compliance of many patients. The study examined the effect of concentration of the artificial sweetener xylitol on the liberation of the active ingredient from prepared hydrogels. The optimum concentration of the artificial sweetener was adjusted to a degree which does not affect the qualitative properties of the active ingredient.

Keywords:
lidocaine hydrochloride, xylitol, hydrogel, liberation

Sources

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