#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Effect of Humectants on Pharmaceutical Availability and Rheological Properties of Cetirizine-Containing Hydrogels


Authors: Z. Capková;  Z. Vitková;  S. Uhrovská
Authors‘ workplace: Farmaceutická fakulta Univerzity Komenského v Bratislave, Katedra galenickej farmácie, SR
Published in: Čes. slov. Farm., 2005; 54, 226-230
Category: Original Articles

Overview

The paper is concerned with the formulation of the antihistamine cetirizine into hydrogels. The cellulose derivatives hydroxyethylcellulose (HEC) and methylcellulose (MC) were employed to prepare hydrogels. As auxiliary substances from the group of humectants are indispensable components of hydrogels, the paper examines their effect (glycerol – GL, propylene glycol – PG, and sorbitol – SO) on the rheological properties and pharmaceutical availability of cetirizine in its formulation into hyrogel. The obtained results show that from the viewpoint of dermal administration for cetirizine at this stage of research hydrogels of the following composition are optimal: 3 %HEC + 15% GL and 2.5% MC + 10% SO.

Key words:
hydrogels – cetirizine hydroxyethylcellulose – methylcellulose – humectants


Labels
Pharmacy Clinical pharmacology
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#