Lack of Response to Intravitreal Ranibizumab Treatment in Adult Onset Foveomacular Vitelliform

Authors: Mustafa Berhuni ¹; Setge Nesime Tıskaoğlu ¹; Cem Ozturkmen ²
Authors‘ workplace: Ersin Arslan Research and Education Hospital, Gaziantep, Turkey ¹; Goznuru Eye Hospital, Gaziantep, Turkey ²
Published in: Čes. a slov. Oftal., 80, 2024, No. Ahead of print, p. 1-3
Category: Case Report
doi: https://doi.org/10.31348/2024/21

Overview

Adult-onset foveomacular vitelliform dystrophy (AOFVD) is a rare disease characterized by accumulation of yellowish deposits in the macula. Rarely, it may be complicated by choroidal neovascularization (CNV). Cases with CNV may be confused with occult CNV in age-related macular degeneration. In our case, we will present the visual and anatomical results of a patient with AOVF-related CNV, in which we administered 3 doses of intravitreal ranibizumab (IVR). A 59-year-old female patient, who attended our clinic with the complaint of decreased vision in both eyes, was diagnosed with AOVF-related CNV in both eyes and was treated with 3 doses of IVR for 3 months. Despite the improvement in visual and anatomical functions 1 month after the first dose, vision decreased, and anatomical functions regressed to the pre-injection state in continued injections. IVR therapy is not an appropriate treatment option in the treatment of AOVF-associated CNV.

Keywords:

anti-VEGF – optic coherence tomography – adult onset vitelliform dystrophy – retinal dystrophy – subretinal deposits

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