Differential Diagnosis of Tauopathies – a Clinical Approach
Authors:
R. Rusina 1,2; R. Matěj 3,4; E. Růžička 1; J. Roth 1
Authors‘ workplace:
Neurologická klinika a Centrum klinických neurověd, 1. LF UK a VFN v Praze
1; Neurologické oddělení, Thomayerova nemocnice, Praha
2; Oddělení patologie a molekulární medicíny, Thomayerova nemocnice, Praha
3; Ústav patologie, 3. LF UK v Praze
4
Published in:
Cesk Slov Neurol N 2015; 78/111(5): 526-534
Category:
Review Article
doi:
https://doi.org/10.14735/amcsnn2015526
Overview
Tauopathies are neurodegenerative disorders characterized by accumulation of abnormally modified forms of the tau-protein, predominantly in frontal, temporal and parietal cortical regions, basal ganglia and in the midbrain. Tauopathies are well defined from the molecular biological and biochemical point of view; clinical symptoms may be, however, heterogeneous. Common signs of frontotemporal lobar degenerations include a more or less prominent syndrome of frontotemporal dementia. On the other hand, the clinical picture of frontotemporal dementia may not be caused by a tauopathy only; in many cases the underlying etiopathogenic cause is different. The aim of our review is to classify the relationship between tauopathies and frontotemporal lobar degenerations. This review contains a proposal of a practical approach to refining clinical diagnosis of the different tauopathies.
Key words:
neurodegeneration – tauopathy – frontotemporal lobar degeneration –progressive supranuclear palsy – progressive aphasia – corticobasal syndrome
The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.
The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.
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Czech and Slovak Neurology and Neurosurgery
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