Treatment by romosozumab in secondary osteoporosis: a review of the literature

Czech version

Authors: Brunerová Ludmila
Authors‘ workplace: Interní klinika 3. LF UK a FNKV, Praha
Published in: Clinical Osteology 2024; 29(1-2): 20-24
Category:

Overview

Osteoporosis represents the most common metabolic bone disease, which affects every third woman and every fifth man worldwide. Low-trauma fractures represent the most serious complications of osteoporosis, responsible for significant morbidity, mortality and increased economical costs. Therapy of osteoporosis is based on three pillars – lifestyle changes, suplementation of vitamin D and calcium and specific antiosteoporotic treatment, which is able to decrease the fracture risk in a half. Romosozumab, a humanized monoclonal antibody against sclerostin has been the most recent anabolic treatment introduced to the Czech market. I tis indicated and reimbursed in postmenopausal women with densitometry osteoporosis and with history of low-trauma fracture, who did not experienced myocardial infarction or stroke. In the following text, original data from studies, identified in PubMed and Medline Plus based on combinations of key words, focusing on the efficacy of romosozumab in specific clinical settings of secondary osteoporosis, is presented.

Keywords:

romosozumab – secondary osteoporosis

Sources

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Article was published in

Clinical Osteology

2024 Issue 1-2