Anisocoria as a side effect of paclitaxel treatment

Czech version

Authors: J. Halámková ¹; D. Adámková Krákorová ¹; R. Demlová ^2,3
Authors‘ workplace: Klinika komplexní onkologické péče LF MU a MOÚ, Brno ¹; Farmakologický ústav, LF MU Brno ²; Oddělení klinického hodnocení, MOÚ Brno ³
Published in: Klin Onkol 2021; 34(4): 306-308
Category: Case Report
doi: https://doi.org/10.48095/ccko2021306

Overview

Background: Paclitaxel is one of the most common cytostatics used in oncology; it is part of the therapeutic protocols of many malignancies. One of its most common side effects is peripheral neuropathy. This symptomatology often leads to a reduction in the dose intensity of chemotherapeutic drugs or to early discontinuation of the treatment. Case: In our case report, we describe a rare case of paclitaxel-induced anisocoria in a young woman with breast cancer. Conclusion: Ocular side effects related to taxanes are rare, with an estimated frequency of about 1%. In addition to relatively frequent obstruction of the nasolacrimal duct, the cystoid macular edema or ischemic retinopathy have been reported. However, in most cases paclitaxel-induced ocular side effects, there is no need to reduce or discontinue therapy. However, the collaboration of an oncologist with an experienced and trained ophthalmologist is essential.

Keywords:

anisocoria – paclitaxel – chemotherapy-induced polyneuropathy – CIPN

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