Implication of Bone Marrow Microenvironment in Pathogenesis of Multiple Myeloma

Czech version

Authors: B. Fišerová; L. Kubiczková; S. Ševčíková; R. Hájek
Authors‘ workplace: Babákova myelomová skupina, Ústav patologické fyziologie, LF MU Brno
Published in: Klin Onkol 2012; 25(4): 234-240
Category: Reviews

Overview

Multiple myeloma is a hematooncological disease characterized by malignant proliferation of plasma cells. These cells accumulate in the bone marrow where they suppress physiological hematopoiesis; at the same time, these cells interact with a wide variety of cytokines, growth factors and adhesion molecules. It is obvious that the bone marrow microenvironment plays an important role in disease pathogenesis as well as treatment resistance.

Key words:
multiple myeloma – bone marrow – IL‑6

This study was supported by scientific program of the Czech Ministry of Education, Youth and Sports No. MSM0021622434, by grant of Czech Science Foundation No. GAP304/10/1395 and by grant of Internal Grant Agency of the Czech Ministry of Health No. NT11154 and NT12130.

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

Submitted:
26. 4. 2012

Accepted:
10. 5. 2012

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