Changes in Immune Reactivity in Cancer Patients
Authors:
J. Kopecký 1; L. Slováček 2; P. Priester 2; MUDr. Birgita Slováčková, Ph.D. 3; O. Kopecký 4,5
Authors‘ workplace:
Klinika onkologie a radioterapie, LF UK a FN Hradec Králové
1; Klinika onkologie a radioterapie, FN Hradec Králové
2; Psychiatrická klinika, FN Hradec Králové
3; Oddělení klinické onkologie, Oblastní nemocnice Náchod a. s.
4; Oddělení klinické imunologie a mikrobiologie, Oblastní nemocnice Náchod a. s.
5
Published in:
Klin Onkol 2012; 25(2): 97-102
Category:
Reviews
Overview
It appears that the long-accepted paradigm that cytostatic and radiation therapy cause only immunosuppression, is not so clearly true. With regard to new knowledge in cancer immunology field, it seems that not only cytostatic and radiation therapy plays an important role in the alteration of immune system. There are many other factors influencing immunity like tumour environment itself, the use of immunomodulatory drugs or even the mental condition of cancer patients. The aim of review is to familiarize physicians with possible alterations of the immune system in cancer patients.
Key words:
immune system – chemotherapy – depression – glucocorticoids – radiotherapy
The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.
The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.
Submitted:
28. 11. 2011
Accepted:
12. 1. 2012
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