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Fixed‑dose triple antihypertensive combination and subclinical organ damage


Authors: P. Wohlfahrt
Authors‘ workplace: Centrum kardiovaskulární prevence, 1. LF UK a Thomayerova nemocnice, PrahaKardiocentrum, Pracoviště preventivní kardiologie, IKEM, PrahaMezinárodní centrum klinického výzkumu, FN u sv. Anny, Brno
Published in: Kardiol Rev Int Med 2015, 17(3): 249-252
Category: Cardiology Review

Overview

Most patients with arterial hypertension require a combination of two or more antihypertensive drugs in order to achieve target levels of blood pressure. On the other hand, with an increasing number of tablets, adherence and persistence with antihypertensive therapy may worsen. Fixed‑dose combination of antihypertensive drugs simplifies therapy for the patient and allows target blood pressure levels to be achieved with a lower number and doses of antihypertensive drugs. In the present case report we describe the positive effect of a new fixed‑dose triple antihypertensive therapy on parameters of subclinical organ damage in a patient with a history of poor adherence to antihypertensive therapy.

Keywords:
arterial hypertension –  fixed‑dose combination –  subclinical organ damage –  left ventricular hypertrophy –  chronic kidney disease


Sources

1. Kumagai N, Onishi K, Hoshino K et al. Improv­ing drug adherence using fixed combinations caused beneficial treatment outcomes and de­creased health‑ care costs in patients with hypertension. Clin Exp Hyperten 2013; 35: 355– 360. doi: 10.3109/ 10641963.2012.732644.

2. 2013 Practice guidelines for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC): ESH/ ESC Task Force for the Management of Arterial Hypertension. J Hypertens 2013; 31: 1925– 1938. doi: 10.1097/ HJH.0b013e328364ca4c.

3. Hsu TW, Liu JS, Hung SC et al. Renoprotective effect of renin‑angiotensin‑aldosterone system blockade in patients with predialysis advanced chronic kidney disease, hypertension, and anemia. JAMA Intern Med 2014; 174: 347– 354. doi: 10.1001/ jamainternmed.2013.12700.

Labels
Paediatric cardiology Internal medicine Cardiac surgery Cardiology

Article was published in

Cardiology Review

Issue 3

2015 Issue 3

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