Vitamin D and cardiovascular diseases
Authors:
H. Matějovská Kubešová; B. Vepřeková 1; P. Weber; K. Bielaková; T. Gregorová
Authors‘ workplace:
Klinika interní, geriatrie a praktického lékařství LF MU a FN Brno-Bohunice
; Nemocnice Milosrdných Bratří, Brno
1
Published in:
Kardiol Rev Int Med 2012, 14(1): 11-13
Overview
Vitamin D and cardiovascular diseases. Lot of attention is paid to vitamin D in last few years due to brighter spectrum of influence in human organs. As a main mechanism of action are proved vitamin nuclear D receptors. More and more evidence of negative influence of vitamin D deficit on cardiovascular system appears together with low vitamin D serum levels in current population mostly due to live style with little exposition of unprotected skin to sun beams. The course of ischemic heart disease can be worsened by low serum level of vitamin D because of higher risk of myocardial infarction a cardiac failure with more frequent hospitalisations. Higher risk of arrythmias during vitamin D deficiency is explained by higher production of parathormone and its binding to receptors stimulating phospholipase C followed by higher activity of catecholamines, angiotensin II and endothelin in ischaemic myocardium. There is no evidence of any association of vitamin D and cholesterol levels, on the other hand normal level of vitamin D helps to keep the triglyceride serum concentration in normal range. Hypertension is influenced negatively by low level of vitamin D by stimulation of renin-angiotensin-ldosteron system, parathormon secretion and lower antiiflammatory and vasculoprotective effect.
Conclusion:
The course of cardiovascular diseases can be positively odulated by keeping of vitamin D level within normal range. The adequate exposition od unprotected skin to sun is to recommend for the supplementation as a nature and effective source of vitamin D.
Keywords:
vitamin D – ischaemic heart disease – cardiac failure – hypertension – sun exposition
Sources
1. Pilz S, Tomaschitz A, März W et al. Vitamin D, cardiovascular disease and mortality. Clin Endocrinol (Oxf) 2011; 75: 575–584.
2. Wu-Wong Jr. Vitamin D therapy in cardiac hypertrophy and heart failure. Curr Pharm Des 2011; 17: 1794–1807.
3. Holick MF. Vitamin D: a d-lightful solution for health. J Investig Med 2011; 59: 872–880.
4. Heine G, Anton K, Henz BM et al. 1alpha, 25-dihydroxyvitamin D3 inhibits anti CD40 plus IL-4 mediated IgE production in vitro. Eur J Immunol 2002; 32: 3395–3404.
5. Sun Q, Shi L, Rimm EB et al. Vitamin D intake and risk of cardiovascular disease in US men and women. Am J Clin Nutr 2011; 94: 534–542.
6. Matějovská Kubešová H. Problematika vitaminu D u seniorů. Gerontologický kongres Hradec Králové, prosinec 2010, sborník abstrakt.
7. Dietary suplement fact sheet: Vitamin D. Office of Dietary Supplements. National Institute of Health 2011; 2: 1–15.
8. Vyskočil V. Vitamin D. Klinická farmakologie a farmacie 2011; 25: 72–75.
9. Vacek JL, Vanga SR, Good M et al. Vitamin D Deficiency and Supplementation and Relation to Cardiovascular Health. Am J Cardiol 2011 Nov 7. [Epub ahead of print].
10. Kestenbaum B, Katz R, de Boer I et al. Vitamin D, parathyroid hormone, and cardiovascular events among older adults. J Am Coll Cardiol 2011; 58: 1433–1441.
11. Dobnig H, Pilz S, Scharnagl H et al. Independent association of low serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin d levels with all-cause and cardiovascular mortality. Arch Intern Med 2008; 168: 1340–1349.
12. Schroten NF, Gaillard CA, van Veldhuisen DJ et al. New roles for renin and prorenin in heart failure and cardiorenal crosstalk. Heart Fail Rev 2011 Jun 22. [Epub ahead of print].
13. Cozzolino M, Ronco C. The impact of paricalcitol on left ventricular hypertrophy. Contrib Nephrol 2011; 171: 161–165.
14. Guessous I, Bochud M, Bonny O et al. Calcium, vitamin D and cardiovascular disease. Kidney Blood Press Res 2011; 34: 404–417.
15. Cioffi G, Gatti D, Adami S. [Vitamin D deficiency, left ventricular dysfunction and heart failure]. G Ital Cardiol (Rome) 2010; 11: 645–653.
16. Meems LM, van der Harst P, van Gilst WH et al. Vitamin D biology in heart failure: molecular mechanisms and systematic review. Curr Drug Targets 2011; 12: 29–41.
17. Linefsky JP, O‘Brien KD, Katz R et al. Association of serum phosphate levels with aortic valve sclerosis and annular calcification: the cardiovascular health study. J Am Coll Cardiol 2011; 58: 291–297.
18. Pilz S, März W, Wellnitz B et al. Association of vitamin D deficiency with heart failure and sudden cardiac death in a large cross-sectional study of patients referred for coronary angiography. J Clin Endocrinol Metab 2008; 93: 3927–3935.
19. Shanker J, Maitra A, Arvind P et al. Role of vitamin D levels and vitamin D receptor polymorphisms in relation to coronary artery disease: the Indian atherosclerosis research study. Coron Artery Dis 2011; 22: 324–332.
20. Lee JH, Gadi R, Spertus JA et al. Prevalence of vitamin D deficiency in patients with acute myocardial infarction. Am J Cardiol 2011; 107: 1636–1638. Epub 2011 Mar 23.
21. Szabó B, Merkely B, Takács I. [The role of vitamin D in the development of cardiac failure]. Orv Hetil 2009; 150: 1397–1402.
22. Patel R, Rizvi AA. Vitamin D deficiency in patients with congestive heart failure: mechanisms, manifestations, and management. South Med J 2011; 104: 325–330.
23. Liu LC, Voors AA, van Veldhuisen DJ et al. Vitamin D status and outcomes in heart failure patients. Eur J Heart Fail 2011; 13: 619–625.
24. Witham MD. Vitamin D in chronic heart failure. Curr Heart Fail Rep 2011; 8: 123–130.
25. Grandi NC, Breitling LP, Brenner H. Vitamin D and cardiovascular disease: systematic review and meta-analysis of prospective studies. Prev Med 2010; 51(3–4): 228–233.
26. Pilz S, Tomaschitz A, Drechsler C et al. Vitamin D deficiency and myocardial diseases. Mol Nutr Food Res 2010; 54: 1103–1113.
27. Zittermann A, Gummert JF, Börgermann J. The role of vitamin D in dyslipidemia and cardiovascular disease. Curr Pharm Des 2011; 17: 933–942.
28. Rienstra M, Cheng S, Larson MG. Vitamin D status is not related to development of atrial fibrillation in the community. Am Heart J 2011; 162: 538–541.
29. Bobkowski W, Nowak A. The importance of magnesium status in the pathophysiology of mitral valve prolapse. Cardiol Rev 2012; 20: 38–44.
30. McCarty MF, Barroso-Aranda J, Contreras F. Can moderate elevations of parathyroid hormone acutely increase risk for ischemic cardiac arrhythmias? 2009; 72: 581–583.
31. Scragg RK, Camargo CA Jr, Simpson RU. Relation of serum 25-hydroxyvitamin D to heart rate and cardiac work (from the National Health and Nutrition Examination Surveys). Am J Cardiol 2010; 105: 122–128.
32. Pilz S, Tomaschitz A. Role of vitamin D in arterial hypertension. Expert Rev Cardiovasc Ther 2010; 8: 1599–1608.
33. Mayer O Jr, Filipovský J, Seidlerová J. The association between low 25-hydroxyvitamin D and increased aortic stiffness. J Hum Hypertens 2011 Oct 20. doi: 10.1038/jhh.2011.94. [Epub ahead of print].
34. Liss Y, Frishman WH. Vitamin D: a cardioprotective agent? Cardiol Rev 2012; 20: 38–44.
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