Characteristics of patients with uncontrolled arterial hypertension and/or dyslipidemia in primary care in Czechia– LipitenCliDec Study: 1^st phase results

Czech version

Authors: Martin Šatný; Jana Mašková; Eva Tůmová; Jiří Laštůvka; Michal Vrablík
Authors‘ workplace: III. interní klinika – klinika endokrinologie a metabolismu 1. LF UK a VFN v Praze
Published in: AtheroRev 2020; 5(1): 47-52
Category: clinical studies

Overview

Introduction: The aim of the observational, multicentre study LipitenCliDec was to map the level of control of cardiovascular (CV) risk factors and characterize the patient population who failed to reach the recommended blood pressure and/or lipid target values in daily practice. Another important outcome of this study should be the capture of patients meeting the criteria for familial hypercholesterolemia (FH) as defined by the MedPed (Make Early Diagnosis to Prevent Early Deaths in Medical Pedigrees) project aimed at early detection and proper treatment of these patients.

Methods: The study was conducted at GPs who offered participation to all consecutive patients diagnosed with arterial hypertension (AH) as well as dyslipidaemia where AH and/or dyslipidaemia are not controlled (blood pressure > 140/90 mm Hg, dyslipidaemia as recommended ESC/EAS Guidelines for management of dyslipidaemia 2016.

Results: Out of the 3769 enrolled patients, 55.3% were males (median age 61 years) and 44.6 % were females (median age 64 years). Lipid profile – mean (standard deviation – SD), [mmol/L]: total cholesterol 5.81 (1.32), LDL-C 3.52 (1.12), HDL-C 1.44 (0.58), non-HDL- C 4.37 (1.32), triglycerides 2.11 (1.37). Blood pressure (BP) – mean (SD), [mm Hg]: systolic BP 143.9 (16.3) and diastolic BP 85.4 (10.5). The proportions of the CV risk categories across the study population were: very high 22.9 %, high 29.5 %, moderate 35.1 % and low 12.6 %. 2627 patients (69.7 %) were eligible for calculation of 10-years CV risk according to the Systematic Coronary Risk Evaluation (SCORE) tables. FH was suspected in 256 (10.6 %) out of the 2 356 patients, who were evaluated for FH diagnosis.

Conclusion: In LipitenCliDec study, CV risk factors were quantified in the target population of patients diagnosed with uncontrolled arterial hypertension (AH) and/or dyslipidaemia by each CV risk category and in total. Most patients in the study population fall into the category of very high and high CV risk due to manifest CV disease, or the presence of diabetes or renal disease.

Keywords:

arterial hypertension – cardiovascular risk factors – dyslipidaemia – familial hypercholesterolemia – study LipitenCliDec

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