Trefoil factor 1 as an indicator of damage of the intestinal mucosa during sepsis in children
Authors:
Žurek Jiří 1,2; Klučková Kateřina 1; Fedora Michal 1,2
Authors‘ workplace:
Klinika dětské anesteziologie a resuscitace LF MU Brno, FN Brno, Lékařská fakulta, Masarykova univerzita, Brno
1; Klinika dětské anesteziologie a resuscitace, Fakultní nemocnice Brno
2
Published in:
Anest. intenziv. Med., 23, 2012, č. 2, s. 83-90
Category:
Intensive Care Medicine - Original Paper
Overview
Objective:
The aim of this study was to determine the levels of TFF1 in paediatric patients with SIRS or a septic condition compared with healthy population levels. The second goal was to compare the levels of TFF1 within the individual septic conditions and the impact of this protein levels on mortality.
Design:
Prospective observational study.
Setting:
Department of Anaesthesiology and Intensive Care Medicine, University Hospital.
Materials and methods:
The study included 57 children aged 0–19 years (30 boys and 27 girls), hospitalized from June 2009 to March 2011, with expected or proven SIRS and a septic condition. The degree of severity was evaluated according to PELOD Score. Blood tests to determine TFF factor levels were taken throughout the period when the patients were meeting the SIRS or sepsis criteria. The control samples were obtained by collecting serum TFF levels from patients undergoing elective surgery.
Results:
TFF1 levels in patients with SIRS or any septic condition were higher than in the control group. TFF1 cut-off for the first day was 2.44 ng/ml, AUC 0.668, p = 0.002, for the third day 1.82 ng/ml, AUC 0.733, p < 0.001 and for the fifth day 1.33 ng/ml, AUC 0.749, p < 0.001.
TFF1 levels in patients with septic shock/MODS were higher than in other groups (p =0.038), but without apparent dynamics of this protein within five days.
Patients who were hospitalized for more than 10 days had significantly higher levels of TFF1, p = 0.032.
Conclusion:
We demonstrated increased expression of protein Trefoil factor 1 during sepsis in the paediatric population.
Keywords:
sepsis – trefoil factor 1 – gut – children – mortality
Sources
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Anaesthesiology, Resuscitation and Inten Intensive Care MedicineArticle was published in
Anaesthesiology and Intensive Care Medicine
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