Influence of age and gender on the pharmacodynamic parameters of rocuronium during total intravenous anaesthesia – a prospective study
Authors:
Adamus Milan 1; Hrabálek Lumír 2; Wanek Tomáš 2; Gabrhelík Tomáš 1; Zapletalová Jana 3,4
Authors‘ workplace:
Klinika anesteziologie, resuscitace a intenzivní medicíny, Fakultní nemocnice a Lékařská fakulta Univerzity Palackého v Olomouci
1; Neurochirurgická klinika, Fakultní nemocnice a Lékařská fakulta Univerzity Palackého v Olomouci
2; Ústav lékařské biofyziky, Lékařská fakulta Univerzity Palackého v Olomouci
3; Institut molekulární a translační medicíny, Lékařská fakulta Univerzity Palackého v Olomouci
4
Published in:
Anest. intenziv. Med., 23, 2012, č. 1, s. 21-27
Category:
Anaesthesiology - Original Paper
Overview
Influence of age and gender on the pharmacodynamic parameters of rocuronium during total intravenous anaesthesia – a prospective study
Objective:
To compare the pharmacodynamics of 0.6 mg . kg-1 rocuronium in young and older patients of both genders during total intravenous anaesthesia.
Design:
Clinical, observational, non-blinded study.
Setting:
Department of Anaesthesiology, University Hospital.
Materials and methods:
Following local ethics committee approval and informed consent, patients scheduled for surgery under total intravenous anesthesia (propofol/sufentanil) were divided into 4 study groups: 37 males aged 20–40, 40 males aged 60–75 yrs, 43 females aged 20–40 and 38 females aged 60–75 yrs. Neuromuscular block following rocuronium (0.6 mg kg-1) was monitored as follows: train-of-four [TOF] stimulation of the ulnar nerve at 15-s intervals, EMG of the adductor pollicis muscle. The onset time (from application of rocuronium to maximum depression of T1), clinical duration (from application to 25% recovery of T1), and time to full spontaneous recovery (from application to TOF-ratio ≥ 0.9) were determined for each patient. The Kruskal-Wallis test was used to compare differences between the groups; P < 0.05 was considered statistically significant.
Results:
The onset time (median [interquartile range]) in the respective groups was 90 [80–110]BCD, 135 [116–165]AC, 75 [60–90]ABD, and 120 [90–146]AC seconds. The clinical duration was 30 [25–42]BCD, 58 [53–67]AD, 50 [40–65]AD, and 85 [70–90]ABC min. The interval to full spontaneous recovery was 59 [51–67]BCD, 102 [75–106]A, 76 [66–91]AD, and 128 [94–137]AC min. (AP<0.05 vs. young males, BP<0.05 vs. elderly males, CP<0.05 vs. young females, DP<0.05 vs. elderly females).
Conclusion:
Females and the elderly were more sensitive to rocuronium.
Keywords:
rocuronium – neuromuscular blockade – age – gender
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