PLOS Genetics - Číslo 5/2012

Perspective

32767

Slowing Replication in Preparation for Reduction

Chromosome Pairing: A Hidden Treasure No More

Interview

32767

Scientist Citizen: An Interview with Bruce Alberts

Research Article

32767

Loss of Imprinting Differentially Affects REM/NREM Sleep and Cognition in Mice

Six Novel Susceptibility Loci for Early-Onset Androgenetic Alopecia and Their Unexpected Association with Common Diseases

Regulation by the Noncoding RNA

UDP-Galactose 4′-Epimerase Activities toward UDP-Gal and UDP-GalNAc Play Different Roles in the Development of

Deletion of PTH Rescues Skeletal Abnormalities and High Osteopontin Levels in Mice

Karyotypic Determinants of Chromosome Instability in Aneuploid Budding Yeast

Genome-Wide Copy Number Analysis Uncovers a New HSCR Gene:

MicroRNA-277 Modulates the Neurodegeneration Caused by Fragile X Premutation rCGG Repeats

Functional Centromeres Determine the Activation Time of Pericentric Origins of DNA Replication in

Dynamic Deposition of Histone Variant H3.3 Accompanies Developmental Remodeling of the Transcriptome

YY1 Regulates Melanocyte Development and Function by Cooperating with MITF

Congenital Heart Disease–Causing Gata4 Mutation Displays Functional Deficits

Recombination Drives Vertebrate Genome Contraction

KATNAL1 Regulation of Sertoli Cell Microtubule Dynamics Is Essential for Spermiogenesis and Male Fertility

Re-Patterning Sleep Architecture in through Gustatory Perception and Nutritional Quality

Using Whole-Genome Sequence Data to Predict Quantitative Trait Phenotypes in

Genome-Wide Analysis of GLD-1–Mediated mRNA Regulation Suggests a Role in mRNA Storage

Meiotic Chromosome Pairing Is Promoted by Telomere-Led Chromosome Movements Independent of Bouquet Formation

LINT, a Novel dL(3)mbt-Containing Complex, Represses Malignant Brain Tumour Signature Genes

The H3K27 Demethylase UTX-1 Is Essential for Normal Development, Independent of Its Enzymatic Activity

Suppresses Senescence Programs and Thereby Accelerates and Maintains Mutant -Induced Lung Tumorigenesis

Genome-Wide Association of Pericardial Fat Identifies a Unique Locus for Ectopic Fat

An Essential Role for Katanin p80 and Microtubule Severing in Male Gamete Production

Identification of Genes That Promote or Antagonize Somatic Homolog Pairing Using a High-Throughput FISH–Based Screen

Principles of Carbon Catabolite Repression in the Rice Blast Fungus: Tps1, Nmr1-3, and a MATE–Family Pump Regulate Glucose Metabolism during Infection

Integrin α PAT-2/CDC-42 Signaling Is Required for Muscle-Mediated Clearance of Apoptotic Cells in

Histone H3 Localizes to the Centromeric DNA in Budding Yeast

Collapse of Telomere Homeostasis in Hematopoietic Cells Caused by Heterozygous Mutations in Telomerase Genes

Hypersensitive to Red and Blue 1 and Its Modification by Protein Phosphatase 7 Are Implicated in the Control of Arabidopsis Stomatal Aperture

Extent, Causes, and Consequences of Small RNA Expression Variation in Human Adipose Tissue

TBC-8, a Putative RAB-2 GAP, Regulates Dense Core Vesicle Maturation in

Regulating Repression: Roles for the Sir4 N-Terminus in Linker DNA Protection and Stabilization of Epigenetic States

Common Genetic Determinants of Intraocular Pressure and Primary Open-Angle Glaucoma

Prdm5 Regulates Collagen Gene Transcription by Association with RNA Polymerase II in Developing Bone

Fitness Landscape Transformation through a Single Amino Acid Change in the Rho Terminator

Repeated, Selection-Driven Genome Reduction of Accessory Genes in Experimental Populations

Allelic Variation and Differential Expression of the mSIN3A Histone Deacetylase Complex Gene Promote Mammary Tumor Growth and Metastasis

DNA Demethylation and USF Regulate the Meiosis-Specific Expression of the Mouse

Knowledge-Driven Analysis Identifies a Gene–Gene Interaction Affecting High-Density Lipoprotein Cholesterol Levels in Multi-Ethnic Populations

A Duplication CNV That Conveys Traits Reciprocal to Metabolic Syndrome and Protects against Diet-Induced Obesity in Mice and Men

EMT Inducers Catalyze Malignant Transformation of Mammary Epithelial Cells and Drive Tumorigenesis towards Claudin-Low Tumors in Transgenic Mice

Inactivation of a Novel FGF23 Regulator, FAM20C, Leads to Hypophosphatemic Rickets in Mice

Genome-Wide Association for Abdominal Subcutaneous and Visceral Adipose Reveals a Novel Locus for Visceral Fat in Women

Stratifying Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants in and Enrichment for Risk Variants in Lean Compared to Obese Cases

New Insight into the History of Domesticated Apple: Secondary Contribution of the European Wild Apple to the Genome of Cultivated Varieties

Activated Cdc42 Kinase Has an Anti-Apoptotic Function

The Region Is Critical for Birth Defects and Electrocardiographic Dysfunctions Observed in a Down Syndrome Mouse Model

COP9 Signalosome Integrity Plays Major Roles for Hyphal Growth, Conidial Development, and Circadian Function

Bmps and Id2a Act Upstream of Twist1 To Restrict Ectomesenchyme Potential of the Cranial Neural Crest

Psip1/Ledgf p52 Binds Methylated Histone H3K36 and Splicing Factors and Contributes to the Regulation of Alternative Splicing

The Number of X Chromosomes Causes Sex Differences in Adiposity in Mice

Target Gene Analysis by Microarrays and Chromatin Immunoprecipitation Identifies HEY Proteins as Highly Redundant bHLH Repressors

Acquisition Order of Ras and p53 Gene Alterations Defines Distinct Adrenocortical Tumor Phenotypes

ELK1 Uses Different DNA Binding Modes to Regulate Functionally Distinct Classes of Target Genes

Histone H1 Depletion Impairs Embryonic Stem Cell Differentiation

IDN2 and Its Paralogs Form a Complex Required for RNA–Directed DNA Methylation

Separation of DNA Replication from the Assembly of Break-Competent Meiotic Chromosomes

Genomic Hypomethylation in the Human Germline Associates with Selective Structural Mutability in the Human Genome

PLOS Genetics

2012 Číslo 5

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