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Real-world data on the efficacy and safety of ibrutinib and venetoclax in patients with chronic lymphocytic leukaemia, a single-centre experience


Authors: F. Farkaš 1;  M. Hrubiško 1,2;  A. Bátorová 1
Authors‘ workplace: Klinika hematológie a transfúziológie LF UK, SZU a UNB, Bratislava, SR 1;  Katedra hematológie a transfúziológie LF SZU, Bratislava, SR 2
Published in: Transfuze Hematol. dnes,28, 2022, No. 2, p. 94-99.
Category: Original Papers
doi: https://doi.org/10.48095/cctahd2022prolekare.cz8

Overview

Introduction: Treatment of chronic lymphocytic leukaemia (CLL) continues to develop dramatically. Chemoimmunotherapy that historically represented the golden standard of treatment has been largely replaced by molecular-targeted therapies that are more effective and safer. Objective: A retrospective study to evaluate the efficacy and safety of innovative „chemo-free“ therapy (ibrutinib and venetoclax) in patients with CLL. Material and methods: from January 2016 to September 2021, 83 patients with chronic lymphocytic leukaemia treated in our institute were included in the study. A total of 63 patients received ibrutinib (15.9% in front-line setting) and 20 patients received venetoclax +/– rituximab (85% as monotherapy and 5% in front-line setting). The median age was 64 years (range 39–81 years). Each group had a median of two prior lines of therapy (range 1–6). The median follow-up was 31 months for ibrutinib and 23 months for venetoclax. Results: the majority of patients responded to treatment with an overall response rate (ORR) of 92% for ibrutinib and 90% for venetoclax. The rate of complete remission was higher with venetoclax (relative risk – RR = 2.02, 95% CI: 1.16–3.5; P = 0.012). The 3-year progression-free survival (PFS) and overall survival (OS) were 82% and 83% for ibrutinib, 80% and 80% for venetoclax respectively. The majority of side effects reported were relatively mild to moderate. Conclusion: In our study, we demonstrate that novel agents, ibrutinib and venetoclax provide comparable results in patients with CLL treated outside clinical trials.

Keywords:

Safety – ibrutinib – venetoclax – chronic lymphocytic leukaemia – efficacy


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