Evolution of chronic lymphocytic leukemia treatment over the past 25 years

Czech version

Authors: T. Papajík; R. Urbanová; P. Turcsányi
Authors‘ workplace: Hemato-onkologická klinika FNOL a LF UP v FN Olomouci
Published in: Transfuze Hematol. dnes,25, 2019, No. 1, p. 72-80.
Category: Review/Educational Papers

Nárůst poznatků o buněčné povaze, patogenezi a genetických změnách chronické lymfocytární leukemie (CLL) spolu s novými možnostmi terapie purinovými analogy a monoklonálními protilátkami v 90. letech minulého století vedly k dalšímu zvýšení zájmu o výzkum této chorobné jednotky. Dosažené poznatky z počátku tohoto století významně pomohly ve vývoji nových cílených léků, které se dnes stávají páteří léčby CLL a zásadním způsobem budou měnit terapeutické algoritmy v budoucích několika příštích letech.

Overview

Advances in understanding the cell origin, pathogenesis, genetic and molecular biology together with introduction of novel agents – purine nucleoside analogues and monoclonal antibodies – led to dynamic changes in the field of chronic lymphocytic leukaemia (CLL) in the 1990s. In the 2000s and 2010s, important biological insights helped develop small targeted drugs that now form the backbone of CLL therapy and will dramatically change therapeutic algorithms in the near future. Modern treatment approaches will most probably be chemotherapy-free for a majority of CLL patients. Optimal combination or sequencing of monoclonal antibodies and targeted molecules may cure a substantial proportion of CLL patients in the next years.

Keywords:

Monoclonal antibodies – chronic lymphocytic leukaemia – pathways inhibitors

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