Pika T., Balcárková J., Lochman P., Minařík J., Jarošová M., Raida L., Bačovský J., Ščudla V.: Progression of multiple myeloma associated with partial „light-chain escape“ phenomenon and secondary t(8;14)
Authors:
T. Pika 1; J. Balcárková 2; P. Lochman 3; J. Minařík 1; M. Jarošová 2; L. Raida 2; J. Bačovský 1; V. Ščudla 1
Authors‘ workplace:
III. interní klinika, LF Univerzity Palackého a Fakultní Nemocnice Olomouc, 2Hemato-onkologická klinika, LF Univerzity Palackého a Fakultní Nemocnice Olomouc, 3Oddělení klinické biochemie a imunohematologie, Fakultní Nemocnice Olomouc
1
Published in:
Transfuze Hematol. dnes,17, 2011, No. 1, p. 30-35.
Category:
Comprehensive Reports, Original Papers, Case Reports
Overview
The authors present the case study of a multiple myeloma patient with a good primary response to induction chemotherapy and high-dose treatment supported by autologous peripheral stem cells. The following early and abrupt progression of the disease was characterised by a clone of the morphologically dedifferentiated population of tumorous cells including the loss of the ability to synthesize complete molecules of the monoclonal immunoglobulin and the overproduction of kappa free light chains. A cytogenetic examination revealed the development of a karyotype and the presence of secondary cytogenetic modifications with an unfavourable prognosis – translocation t(8;14) (q24;q32) and increased number of copies of the 1q21 area. The myeloma progression was associated with the subsequent resistance to a state-of-the-art combined therapy.
Key words:
multiple myeloma, immunoglobulin light chains, cytogenetics, t(8;14)
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Vypracováno s podporou VZ MŠMT ČR 6198959205.
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