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Závažné zlyhávanie srdca a arytmia po protinádorovej liečbe podávanej v detstve


Authors: Xénia Faktorová 1;  Milan Luknár 2,3;  Zuzana Zelinková 1;  Lucia Horniaková 4;  Eva Mikušková 5;  Michal Šašov 6;  Mária Szántová 4;  Viliam Mojto 4;  Beata Mladosievičová 7
Authors‘ workplace: Department of Internal Medicine of the Slovak Medical University, University Hospital – St. Michael’s Hospital, a. s, Bratislava 1;  Department of Heart Failure and Heart Transplantation National Institute of Cardiovascular Diseases, Bratislava 2;  Department of Cardiology, Faculty of Medicine, Comenius University and National Institute of Cardiovascular Diseases, Bratislava 3;  Department of Oncohematology Faculty of Medicine, Comenius University and National Cancer Institute, Bratislava 5;  Department of Arrhytmias and Cardiac Stimulation National Institute of Cardiovascular Diseases, Bratislava 6;  Institute of Pathological Physiology, Department of Clinical Pathophysiology, Faculty of Medicine, Comenius University, Bratislava 7;  rd Department of Internal Medicine, Faculty of Medicine, Comenius University and University Hospital, Bratislava 43
Published in: Vnitř Lék 2022; 68(E-1): 22-26
Category: Case reports

Overview

Cieľom kazuistiky je popísať prípad mladého pacienta, v detstve úspešne liečeného pre non-Hodgkinov lymfóm chemoterapiou s obsahom anthracyklínu doxorubicínu s neskorším rozvojom príznakov závažného kardiovaskulárneho poškodenia 27 rokov od diagnostiky lymfómu. Pacient je dlhodobo v kompletnej remisii onkologického ochorenia. U pacienta bola započatá liečba chronického srdcového zlyhávania v súlade s najnovšími odporúčaniami vrátane implantácie kardioverter-defibrilátora, ako primárnej prevencie náhlej kardiálnej smrti. Momentálne je pacient čakateľom na transplantáciu srdca.

Klíčová slova:

srdcové zlyhávanie – antracyklíny – implantovatelný kardioverter-defibrilátor – arytmia – neskorá kardiotoxicita


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