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Disconnected pancreatic duct syndrome – a neglected complication of acute pancreatitis


Authors: Vaněk P. 1,2;  Falt P. 1,3;  Urban O. 1
Authors‘ workplace: II. interní klinika – gastroenterologická a geriatrická LF UP a FN Olomouc 1;  Division of Gastroenterology, Hepatology and Nutrition, University of Minnesota, MN, USA 2;  II. interní gastroenterologická klinika LF UK v Hradci Králové 3
Published in: Gastroent Hepatol 2020; 74(3): 204-211
Category: Digestive Endoscopy: Review Article
doi: https://doi.org/10.14735/amgh2020204

Overview

Acute pancreatitis is a reversible pancreatic inflammatory process that may be accompanied by local and systemic complications. In a subset of patients with severe acute pancreatitis, necrosis affecting the major pancreatic duct may result in a discontinuity between the left-sided pancreas and duodenum. Such an interruption in the setting of a viable upstream portion of gland parenchyma gives rise to the disconnected pancreatic duct syndrome, which is generally regarded as a dia­gnostically and therapeutically difficult condition. The syndrome is associated with a prolonged disease course and poses a burden on patients’ quality of life and high health care resource utilization. There are currently no universally accepted guidelines for the dia­gnosis and treatment, the syndrome is often neglected and dia­gnosis delayed. The aim of our review article is to raise awareness of this serious complication of acute pancreatitis.

Keywords:

Pancreatitis – acute necrotizing pancreatitis – pancreatic ducts – disconnected pancreatic duct syndrome – walled-off necrosis – pancreatic pseudocyst – pancreatic fistula


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