Structure and function of the intestinal epithelial barrier

Czech version

Authors: P. Polák ^1,2; J. Juránková ^3,4; P. Husa ^1,2
Authors‘ workplace: LF MU Brno ¹; Klinika infekčních chorob FN Brno ²; Katedra laboratorních metod LF MU Brno ³; Oddělení klinické mikrobiologie, FN Brno ⁴
Published in: Gastroent Hepatol 2013; 67(6): 494-497
Category: Clinical and Experimental Gastroenterology: Review Article

Overview

In recent years, there has been a revolutionary outbreak of our knowledge about ultra-/structure and function of the intestinal epithelial barrier. During evolution acquisited ability of the macroorganism to dynamically coordinate the interaction with the complexe colonizing microbial ecosystem has been recently shown to be crucial in the health and in the illness-prevention. As acute as chronic pathological conditions, primarilly infectious or non-infectious, may lead to disruption of the intestinal epithelial barrier. The presented overview summarises actual knowledge about structure and function of the intestinal epithelial barrier.

Key words:
intestinal epithelial barrier – tight junctions – infection

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE „uniform requirements“ for biomedical papers.

Submitted:
8. 8. 2013

Accepted:
18. 11. 2013

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