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Forenzně toxikologické dopady pleurálního výpotku; autoptický případ předávkování drogami


: Naoko Tanaka 1;  Hiroshi Kinoshita 1;  Azumi Kuse 2;  Mayo Takatsu 3;  Mostofa Jamal 1;  Mitsuru Kumihashi 1;  Yasushi Nagasaki 3;  Migiwa Asano 2;  Yasuhiro Ueno 2;  Kiyoshi Ameno 1
: Department of Forensic Medicine, Faculty of Medicine, Kagawa University 1;  Division of Legal Medicine, Department of Environmental Health and Safety, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan 2;  Hyogo Medical Examiners Office, Arata-cho 2-1-31, Hyogo-ku, Kobe, 652-0032, Japan 3;  -1, Miki, Kita, Kagawa, 761-079 , Japan 1750
: Soud Lék., 57, 2012, No. 3, p. 48-50
: Original Article

Prezentujeme případ smrtelné otravy psychotropními drogami. Kvantitativní toxikologická analýza prokázala ve femorální krvi tyto koncentrace fenobarbitalu, promethazinu, chlorpromazinu, alprazolamu a bromazepamu: 69.51μg/ml, 32.73μg/ml 24.76μg/ml, 0.04μg/ml and 0.31μg/ml; velké množství těchto látek bylo prokázáno i v žaludečním obsahu. Soudíme, že příčinou smrti bylo především předávkování fenobarbitalem, promethazinem a chlorpromazinem při jejich masivní ingesci. Dále diskutujeme přínos pleurálního výpotku jako alternativního vzorku pro toxikologické vyšetření.

Keywords:
mnohočetné drogy – otrava – kapalinová chromatografie s hmotnostní spektrometrií – fenobarbital – pleurální výpotek


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