Forenzně toxikologické dopady pleurálního výpotku; autoptický případ předávkování drogami

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: Naoko Tanaka ¹; Hiroshi Kinoshita ¹; Azumi Kuse ²; Mayo Takatsu ³; Mostofa Jamal ¹; Mitsuru Kumihashi ¹; Yasushi Nagasaki ³; Migiwa Asano ²; Yasuhiro Ueno ²; Kiyoshi Ameno ¹
: Department of Forensic Medicine, Faculty of Medicine, Kagawa University ¹; Division of Legal Medicine, Department of Environmental Health and Safety, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan ²; Hyogo Medical Examiners Office, Arata-cho 2-1-31, Hyogo-ku, Kobe, 652-0032, Japan ³; -1, Miki, Kita, Kagawa, 761-079 , Japan ¹⁷⁵⁰
: Soud Lék., 57, 2012, No. 3, p. 48-50
: Original Article

Prezentujeme případ smrtelné otravy psychotropními drogami. Kvantitativní toxikologická analýza prokázala ve femorální krvi tyto koncentrace fenobarbitalu, promethazinu, chlorpromazinu, alprazolamu a bromazepamu: 69.51μg/ml, 32.73μg/ml 24.76μg/ml, 0.04μg/ml and 0.31μg/ml; velké množství těchto látek bylo prokázáno i v žaludečním obsahu. Soudíme, že příčinou smrti bylo především předávkování fenobarbitalem, promethazinem a chlorpromazinem při jejich masivní ingesci. Dále diskutujeme přínos pleurálního výpotku jako alternativního vzorku pro toxikologické vyšetření.

Keywords:
mnohočetné drogy – otrava – kapalinová chromatografie s hmotnostní spektrometrií – fenobarbital – pleurální výpotek

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Article was published in

Forensic Medicine

2012 Issue 3