Infekce a kolonizace Clostridium difficile u dětí do 3 let věku: prospektivní srovnávací studie
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V. Musil 1; L. Homola 1; M. Vrba 2; A. Braunová 1; T. Kravalová 1; M. Malá 1; L. Krbková 1
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Department of Pediatric Infectious Diseases, Faculty of Medicine, Masaryk University, University Hospital, Brno, Czech Republic
1; Department of Clinical Microbiology, University Hospital, Brno, Czech Republic
2
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Epidemiol. Mikrobiol. Imunol. 68, 2019, č. 2, s. 59-64
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Original Papers
Cíl: Navzdory narůstajícímu trendu klostridiové kolitidy a vysoké míře kolonizace Clostridium difficile mezi mladšími dětskými pacienty, malé dětí zůstávají k nemoci poměrně rezistentní. Cílem studie bylo rozlišit, zda existuje rozdíl v klostridiové kolitidě mezi dětmi s průjmem a bez průjmu, určit počet záchytů klostridiové kolitidy ve sledované skupině, zhodnotit závažnost klostridiové kolitidy u dětí do 3 let věku s průjmem.
Metody: Prospektivní hodnocení bylo vedeno od května 2015 do června 2016. Děti mladší 3 let byly zapsány do dvou skupin. Každý vzorek stolice byl testován dvoustupňovým algoritmem zahrnující imunochromatografický test a polymerázovou řetězovou reakci.
Výsledky: Zapsáno 147 pacientů s průjmem a 75 kontrol. Počet záchytů klostridiové kolitidy u dětí s průjmem byl 2 % (3/147), počet záchytů toxigenních kmenů ve skupině s průjmem ve srovnání s kontrolní skupinou byl 11,6 % (3/147) vs. 10,6 % (8/75) (p < 0,9999).
Závěr: Nebyl pozorován žádný významný rozdíl mezi dětmi s průjmem a bez průjmu. Nedoporučujeme cíleně vyšetřovat děti na Clostridium difficile při absenci rizikových faktorů.
Klíčová slova:
deti – průjem – Clostridium difficile – novorozenci – pediatrie – kolonizace
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Hygiene and epidemiology Medical virology Clinical microbiologyArticle was published in
Epidemiology, Microbiology, Immunology
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