Ganglioneuróm s perineurálnou diferenciáciou. Kazuistika
Authors:
M. Zámečník 1; A. Chlumská 2,3; F. Ondriaš 1
Authors‘ workplace:
Alpha Medical Pathology, s. r. o., Bratislava, Slovak Republic
1; Šikl`s Department of Pathology, Faculty Hospital, Charles University, Pilsen, Czech Republic
2; Laboratory of Surgical Pathology, Pilsen, Czech Republic
3
Published in:
Čes.-slov. Patol., 48, 2012, No. 2, p. 94-96
Category:
Original Articles
Overview
Prezentovaný je prípad ganglioneurómu s neobvyklou perineurálnou diferenciáciou. Jednalo sa o tumor mediastína u 34-ročného muža. Histologicky obsahoval neuroidné zväzky blandných vretenovitých buniek, zrelé gangliové bunky a ložiskovú adipocytárnu metapláziu. Imunohistochemicky vykazoval tumor očakávané expresie S100 proteinu, kalretinínu a neurofilament proteinu. Prekvapujúcou bola pozitivita početných buniek na perineurálne markery EMA, klaudín-1 a GLUT-1. Jednalo sa často o bunky v organoidnom usporiadaní okolo S100-pozitívnych schwannoidných zväzkov. Prezentovaný prípad ukazuje, že elementy ganglioneurómu sa môžu diferencovať do fenotypu bunky Schwannovej i perineurálnej.
Kľúčové slová:
ganglioneuróm – perineurióm – EMA – claudin-1 – GLUT-1
Sources
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Czecho-Slovak Pathology
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