A new target in the treatment of psoriatic arthritis. Why interleukin-17?
Authors:
L. Šedová
Authors‘ workplace:
Revmatologický ústav, Praha
Published in:
Čes. Revmatol., 27, 2019, No. 2, p. 78-85.
Category:
Review Article
Overview
Interleukin 17 is a pro-inflammatory cytokine that plays an important role in the development of psoriasis, psoriatic arthritis and other autoimmune diseases. It is produced by various cells, especially Th17 lymphocytes. Its inhibition has a pronounced anti-inflammatory effect, manifested, for example, by the suppression of psoriasis skin manifestations and by the reduction of psoriatic arthritis activity. The pathway to achieve inhibition of IL-17 is the use of monoclonal antibodies against IL-17 as well as its receptors, through antibodies against the p40 subunit shared by IL-12 and 23, and preventing their interaction with the receptor, subsequent signalling, differentiation, and cytokine production, including IL-17. IL-17 inhibitors are a new, very effective generation of psoriasis biological therapy, as well as a significant extension of the biological spondyloarthritis therapies to the first drugs with a new, different mechanism of action. Therefore, IL-17 inhibitors represent similar advances as TNF-α inhibitors in rheumatoid arthritis years ago.
Keywords:
Psoriasis – biological therapy – anti-TNF-α – anti-IL-12/23 – IL-17 – anti-IL-17 – Psoriatic arthritis
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Dermatology & STDs Paediatric rheumatology RheumatologyArticle was published in
Czech Rheumatology
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