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Down’s Syndrome in the CR in 1961 - 1997


Authors: A. Šípek 1;  V. Gregor 2;  J. Horáček 2;  M. Chudobová 3
Authors‘ workplace: Ústav pro péči o matku a dítě, Praha - Podolí, ředitel Ing. V. Wollmuth 2 Institut postgraduálního vzdělávání ve zdravotnictví, Praha, Ústav lékařské genetiky, vedoucí prof. MUDr. M. Kučerová, DrSc. 3 Ústav zdravotnických informací a statistiky České repu
Published in: Ceska Gynekol 1999; (3): 173-179
Category:

Overview

During the period from 1961 - 1997 the prevalence of Down’s syndrome (DS) wasfollowed up on the territory of the Czech Republic. From a consecutive series of 5 319 002 birthsin the CR during 1961 - 1997 4 933 cases of DS were diagnosed, incl. 4 410 in born infants and 523were diagnosed prenatally and these pregnancies were terminated. The mean incidence of DS inborn children during the investigation period was 7.91 per 10 000 liveborn infants. When theresults of prenatal diagnosis of DS are added the mean incidence was 9.47 per 10 000 livebornchildren. The prenatal diagnosis of DS in the CR was also investigated. The success rate ofprenatal diagnosis of DS in the CR increased during the period from 1980 - 1997 to as much as 60%of detected cases. In 37.31% of all cases of Down’s syndrome another inborn defect was found,most frequently inborn heart disease, defects of the central nervous system, gastrointestinal andurogenital tract. The age distribution of DS indicates a significantly increased risk for mothersalready from the age of 34 years.

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Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine
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