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Liečebné režimy neovaskulárnej formy vekom podmienenej makulárnej degenerácie. Prehľad

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Authors: Zlatica Fellner 1,2;  Nora Majtánová 1,2;  Petr Kolář 1,2;  Petra Krišková 1;  Petra Kéri 1
Authors‘ workplace: Očná klinika Slovenskej zdravotníckej univerzity a Univerzitnej nemocnice Bratislava 1;  Lekárska fakulta, Slovenská zdravotnícka univerzita, Bratislava 2
Published in: Čes. a slov. Oftal., 80, 2024, No. 6, p. 287-293
Category: Review Article
doi: https://doi.org/10.31348/2024/25

Overview

Článok podáva prehľad o liečebných režimoch liečiv s obsahom antivaskulárneho endotelového rastového faktora na liečbu neovaskulárnej formy vekom podmienenej makulárnej degenerácii. V súčasnosti sú liečivá s obsahom antivaskulárneho endotelového rastového faktora jedinou účinnou liečbou tohto chronického a progredujúceho ochorenia. Liečebné režimy tohto ochorenia v posledných dvoch desaťročiach zaznamenali posun od obyčajnej snahy o stabilizáciu choroby k dosiahnutiu maximálneho zlepšenia zrakovej ostrosti a jej udržanie so zlepšením kvality života pacienta a minimálnou liečebnou záťažou pacienta a jeho rodiny. Ďalšími cieľmi alternatívnych dávkovacích režimov, ktoré nahradili pôvodné fixné režimy boli väčšia individualizácia dávkovacieho režimu, lepšia spolupráca pacienta, šetrenie finančných nákladov a zníženie záťaže v aplikačných centrách. Vekom podmienená makulárna degenerácia, či jej suchá forma alebo vlhká forma predstavuje závažný zdravotný a socioekonomický problém, nakoľko ochorenie patrí medzi najčastejšiu príčinu závažnej a ireverzibilnej poruchy centrálnej zrakovej ostrosti až na úroveň praktickej slepoty jedného alebo obidvoch očí u ľudí nad 50 rokov vo vyspelých priemyselných krajinách. Najdôležitejšia je skorá diagnostika tohto ochorenia a následne promptná a kontinuálna liečba individualizovaným proaktívnym liečebným režimom s cieľom stabilizovať a zlepšiť anatomické a funkčné výsledky.

Klíčová slova:

režimy liečby – vaskulárne endotelové rastové faktory – antivaskulárne endotelové rastové faktory – neovaskulárna forma vekom podmienenej makulárnej degenerácie

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