Cyclins D in Regulation and Dysregulation of the Cell Cycle in Multiple Myeloma
Authors:
L. Kubiczková 1,2; M. Dúcka 1; L. Sedlaříková 1; F. Kryukov 1; R. Hájek 1,2; S. Ševčíková 1,2
Authors‘ workplace:
Babákova myelomová skupina, Ústav patologické fyziologie, LF MU, Brno
1; Oddělení klinické hematologie, FN Brno
2
Published in:
Klin Onkol 2013; 26(5): 313-318
Category:
Review
Overview
Multiple myeloma is the second most common hematooncological disease characterized by clonal proliferation of plasma cells and monoclonal immunoglobulin production. It is a heterogenous disease; however, dysregulation of cyclins D seems to be an early unifying pathogenic event in multiple myeloma. In almost all patients, there is increased expression level of at least one of the cyclins D. Nevertheless, the mechanism of this increase is unknown in many cases. Next to well‑known roles of cyclins D in the cell cycle, they have many other functions contributing to tumor cell progression. Cyclins D are prognostic markers and are also used for subclassification of multiple myeloma. In this review, we focus on significance of cyclins D in multiple myeloma.
Key words: Submitted: Accepted:
multiple myeloma – cyclin D – pathogenesis – cell cycle regulation – TC groups
This study was supported by scientific program of the Czech Ministry of Education, Youth and Sports MSM0021622434, Grant of the Ministry of Health NT14575, NT12130 and NT13190 and internal grant of Faculty of Medicine, Masaryk Univerzity MUNI/11/InGA17/2012.
The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.
The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.
12. 5. 2013
6. 6. 2013
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