Metastatic Renal Cell Carcinoma Treated with Everolimus – Data from the RENIS Clinical Registry
Authors:
T. Büchler 1; L. Dušek 2; J. Fínek 3; A. Poprach 4; D. Budňáková 2; V. Kandrnal 2; J. Jarkovský 2; Z. Bortlíček 2; D. Klimeš 2; J. Abrahámová 1; R. Vyzula 4
Authors‘ workplace:
Onkologické oddělení, Fakultní Thomayerova nemocnice a 1. lékařská fakulta Univerzity Karlovy, Praha
1; Institut biostatistiky a analýz, Lékařská a Přírodovědecká fakulta Masarykovy univerzity, Brno
2; Radioterapeutické a onkologické oddělení, Fakultní nemocnice Plzeň
3; Klinika komplexní onkologické péče, Masarykův onkologický ústav, Brno
4
Published in:
Klin Onkol 2011; 24(5): 389-392
Category:
Reports from Clinical Registries
Overview
Everolimus is an oral mTOR kinase inhibitor approved for the treatment of patients with metastatic renal cell carcinoma (mRCC) progressing during or after treatment with vascular endothelial growth factor (VEGF)-targeted agents. Using the national RENIS clinical registry, we have retrospectively analysed outcomes of patients treated for mRCC with everolimus. A total of 78 patients were evaluable. Median progression-free survival from the start of everolimus therapy was 7 months (95% confidence interval 2–12 months). Partial response or stable disease was achieved in 69% of patients. Treatment toxicity was predictable and serious adverse events occurred in only 6% of patients the most common being respiratory toxicity. Everolimus therapy provides significant clinical benefit for heavily pretreated mRCC patients after failure of VEGF-targeted therapy
Key words:
everolimus – renal cell carcinoma – therapy
The team of autors declares a support of Novartis.
The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.
Submitted:
14. 6. 2011
Accepted:
18. 7. 2011
Sources
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Labels
Paediatric clinical oncology Surgery Clinical oncologyArticle was published in
Clinical Oncology
2011 Issue 5
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