Dyslipidaemia in selected endocrine disorders
Authors:
M. Šatný; M. Vráblík
Authors‘ workplace:
Centrum preventivní kardiologie III. interní kliniky – kliniky endokrinologie a metabolismu 1. LF UK a VFN v Praze
Published in:
Kardiol Rev Int Med 2018, 20(3): 188-196
Overview
Plasma hormone concentrations are closely linked to lipid metabolism, which may be affected both positively and negatively by the hormones. These changes may occur in the context of a different endocrine disorder (prolactinoma, growth hormone deficiency, acromegaly, thyroid disorders, hypogonadism, polycystic ovary syndrome etc.) or during the administration of various hormones in different clinical indications (hormone replacement therapy in menopause, hormonal contraceptives or androgen deprivation therapy). Dyslipidaemia seen in prolactinomas, growth hormone deficiency, male hypogonadism, polycystic ovary syndrome, androgen deprivation therapy or oestrogen deficiency may contribute to an increased risk of atherosclerotic cardiovascular disease. An adequate causal treatment is always the first step. If this does not lead to amelioration of the dyslipidaemia, starting an appropriate lipid-lowering therapy after evaluating the individual cardiovascular risk should be considered.
Key words:
dyslipidaemia – endocrine disorders – cardiovascular risk – lipid-lowering therapy
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