Gabapentinoids in the perioperative period

Czech version

Authors: O. Gimunová; J. Zemanová
Authors‘ workplace: Klinika anesteziologie, resuscitace a intenzivní medicíny, Fakultní nemocnice Brno, a Lékařská fakulta Masarykovy Univerzity v Brně
Published in: Anest. intenziv. Med., 32, 2021, č. 1, s. 25-29
Category: Review Articles

Overview

Multimodal analgesia is predicated on interactions of medicines whereby benefits of combination exceed the risks. Perioperative gabapentinoids have significant adverse effects. Gabapentinoids, when combined with opioids, confer even greater respiratory risk than opioids alone. Routine perioperative administration of gabapentinoids is not more recommended. New clinical trials to evaluate analgesic benefits of gabapentinoids on postoperative pain are very unlikely to provide any new evidence.

Keywords:

history of gabapentinoids – evidence of risk – perioperative period – multimodal analgesia

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