PLOS Genetics - Číslo 1/2015

Perspective

32767

The Combination of Random Mutagenesis and Sequencing Highlight the Role of Unexpected Genes in an Intractable Organism

Ataxin-3, DNA Damage Repair, and SCA3 Cerebellar Degeneration: On the Path to Parsimony?

α-Actinin-3: Why Gene Loss Is an Evolutionary Gain

Regulating Maf1 Expression and Its Expanding Biological Functions

A Polyubiquitin Chain Reaction: Parkin Recruitment to Damaged Mitochondria

Review

32767

End of the Beginning: Elongation and Termination Features of Alternative Modes of Chromosomal Replication Initiation in Bacteria

The Genetic and Mechanistic Basis for Variation in Gene Regulation

Research Article

32767

Origins of Context-Dependent Gene Repression by Capicua

Transposable Elements Contribute to Activation of Maize Genes in Response to Abiotic Stress

No Evidence for Association of Autism with Rare Heterozygous Point Mutations in Contactin-Associated Protein-Like 2 (), or in Other Contactin-Associated Proteins or Contactins

Nur1 Dephosphorylation Confers Positive Feedback to Mitotic Exit Phosphatase Activation in Budding Yeast

A Regulatory Hierarchy Controls the Dynamic Transcriptional Response to Extreme Oxidative Stress in Archaea

Genetic Variants Modulating CRIPTO Serum Levels Identified by Genome-Wide Association Study in Cilento Isolates

Small RNA Sequences Support a Host Genome Origin of Satellite RNA

Phosphorylation of Elp1 by Hrr25 Is Required for Elongator-Dependent tRNA Modification in Yeast

Genetic Mapping of MAPK-Mediated Complex Traits Across

An AP Endonuclease Functions in Active DNA Demethylation and Gene Imprinting in

Developmental Regulation of the Origin Recognition Complex

Naturally Occurring Differences in CENH3 Affect Chromosome Segregation in Zygotic Mitosis of Hybrids

Imputation of the Rare G84E Mutation and Cancer Risk in a Large Population-Based Cohort

Polycomb Protein SCML2 Associates with USP7 and Counteracts Histone H2A Ubiquitination in the XY Chromatin during Male Meiosis

A Genetic Strategy for Probing the Functional Diversity of Magnetosome Formation

Interactions of Chromatin Context, Binding Site Sequence Content, and Sequence Evolution in Stress-Induced p53 Occupancy and Transactivation

The Yeast La Related Protein Slf1p Is a Key Activator of Translation during the Oxidative Stress Response

Integrative Analysis of DNA Methylation and Gene Expression Data Identifies as a Key Regulator of COPD

Proteasomes, Sir2, and Hxk2 Form an Interconnected Aging Network That Impinges on the AMPK/Snf1-Regulated Transcriptional Repressor Mig1

Functional Interplay between the 53BP1-Ortholog Rad9 and the Mre11 Complex Regulates Resection, End-Tethering and Repair of a Double-Strand Break

Estrogenic Exposure Alters the Spermatogonial Stem Cells in the Developing Testis, Permanently Reducing Crossover Levels in the Adult

Protein Poly(ADP-ribosyl)ation Regulates Immune Gene Expression and Defense Responses

Sumoylation Influences DNA Break Repair Partly by Increasing the Solubility of a Conserved End Resection Protein

A Discrete Transition Zone Organizes the Topological and Regulatory Autonomy of the Adjacent and Genes

Elevated Mutation Rate during Meiosis in

The Intersection of the Extrinsic Hedgehog and WNT/Wingless Signals with the Intrinsic Hox Code Underpins Branching Pattern and Tube Shape Diversity in the Airways

MiR-24 Is Required for Hematopoietic Differentiation of Mouse Embryonic Stem Cells

Tissue-Specific Effects of Genetic and Epigenetic Variation on Gene Regulation and Splicing

Heterologous Aggregates Promote Prion Appearance via More than One Mechanism

The Tumor Suppressor BCL7B Functions in the Wnt Signaling Pathway

, A -Acting Locus that Controls Chromosome-Wide Replication Timing and Stability of Human Chromosome 15

RecFOR Is Not Required for Pneumococcal Transformation but Together with XerS for Resolution of Chromosome Dimers Frequently Formed in the Process

An Intracellular Transcriptomic Atlas of the Giant Coenocyte

Insight in Genome-Wide Association of Metabolite Quantitative Traits by Exome Sequence Analyses

The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3’-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis

The Global Regulatory Architecture of Transcription during the Cell Cycle

Identification and Functional Characterization of Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the Locus

Altered Ca Kinetics Associated with α-Actinin-3 Deficiency May Explain Positive Selection for Null Allele in Human Evolution

Genetic Variation in the Nuclear and Organellar Genomes Modulates Stochastic Variation in the Metabolome, Growth, and Defense

PRDM9 Drives Evolutionary Erosion of Hotspots in through Haplotype-Specific Initiation of Meiotic Recombination

Transcriptional Control of an Essential Ribozyme in Reveals an Ancient Evolutionary Divide in Animals

ALIX and ESCRT-III Coordinately Control Cytokinetic Abscission during Germline Stem Cell Division

Century-scale Methylome Stability in a Recently Diverged Lineage

A Re-examination of the Selection of the Sensory Organ Precursor of the Bristle Sensilla of

Antagonistic Cross-Regulation between Sox9 and Sox10 Controls an Anti-tumorigenic Program in Melanoma

A Dependent Pool of Phosphatidylinositol 4,5 Bisphosphate (PIP) Is Required for G-Protein Coupled Signal Transduction in Photoreceptors

Deciphering the Genetic Programme Triggering Timely and Spatially-Regulated Chitin Deposition

Aberrant Gene Expression in Humans

Fascin1-Dependent Filopodia are Required for Directional Migration of a Subset of Neural Crest Cells

The SWI2/SNF2 Chromatin Remodeler BRAHMA Regulates Polycomb Function during Vegetative Development and Directly Activates the Flowering Repressor Gene

Evolutionary Constraint and Disease Associations of Post-Translational Modification Sites in Human Genomes

A Truncated NLR Protein, TIR-NBS2, Is Required for Activated Defense Responses in the Mutant

Inactivation of PNKP by Mutant ATXN3 Triggers Apoptosis by Activating the DNA Damage-Response Pathway in SCA3

DNA Damage Response Factors from Diverse Pathways, Including DNA Crosslink Repair, Mediate Alternative End Joining

hnRNP K Coordinates Transcriptional Silencing by SETDB1 in Embryonic Stem Cells

PLOS Genetics

2015 Číslo 1

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